PARD6B: Structure, Function and Therapeutic Applications (G84612)

Target Name: PARD6B

NCBI ID: G84612

PARD6B

PARD6B: Structure, Function and Therapeutic Applications

PARD6B (Partitioning defective 6 homolog beta) is a gene that encodes a protein known for its role in intracellular signaling. The protein is involved in the regulation of various cellular processes, including cell adhesion, migration, and invasion. PARD6B has also been implicated in the development and progression of various diseases, including cancer. As a result, PARD6B has become a focus of interest for researchers and pharmaceutical companies alike.

PARD6B: Structure and Function

PARD6B is a member of the Pardin gene family, which is characterized by the presence of a specific conserved domain called PARD (Protein-Protein Interaction domain). This domain is known to play a crucial role in the regulation of protein-protein interactions and is involved in the formation of protein aggregates. PARD6B contains four exons, which result in a protein with four amino acid residues at its C-terminus.

The function of PARD6B is closely tied to its structure. PARD6B is involved in the regulation of cellular processes that require the formation of tight junctions, which are specialized barriers that mediate intercellular communication. tight junctions are essential for maintaining tissue structure and function, as they help to prevent excessive water and ion movement between cells.

PARD6B is also involved in the regulation of cell adhesion and migration. During the cell cycle, PARD6B helps to maintain the integrity of the cytoskeleton and plays a role in the regulation of cell division. In addition, PARD6B is involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed.

PARD6B and Disease

PARD6B has been implicated in the development and progression of various diseases, including cancer. For example, studies have shown that high levels of PARD6B are associated with the development of breast cancer. Additionally, PARD6B has also been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

In addition to its potential involvement in disease, PARD6B is also a drug target. Researchers have identified several potential small molecules that can inhibit the activity of PARD6B and are currently studying their potential therapeutic applications. These small molecules have the potential to be used in the treatment of various diseases, including cancer, neurodegenerative diseases, and chronic pain.

PARD6B as a Drug Target

One of the most promising aspects of PARD6B is its potential as a drug target. Researchers have identified several small molecules that can inhibit the activity of PARD6B and are currently studying their potential therapeutic applications. These small molecules have the potential to be used in the treatment of various diseases, including cancer, neurodegenerative diseases, and chronic pain.

One of the most promising small molecules is a compound called Y1-366. This compound is currently being studied for its potential therapeutic applications in cancer, neurodegenerative diseases, and chronic pain. Y1-366 is a small molecule that can inhibit the activity of PARD6B and has been shown to have therapeutic effects in these conditions.

Another small molecule that is being studied for its potential therapeutic applications is called P1-251. This compound is also being investigated for its ability to inhibit the activity of PARD6B. P1-251 has been shown to have therapeutic effects in cancer and neurodegenerative diseases.

Conclusion

PARD6B is a gene that encodes a protein involved in the regulation of various cellular processes, including cell adhesion, migration, and invasion. PARD6B has also been implicated in the development and progression of various diseases, including cancer. As a result, PARD6B has become a focus of interest for researchers and pharmaceutical companies alike.

The structure and function of PARD6B are closely tied to its involvement in cellular processes. PARD6B is involved in the regulation of tight

Protein Name: Par-6 Family Cell Polarity Regulator Beta

Functions: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins

The "PARD6B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PARD6B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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