Target Name: MCOLN1
NCBI ID: G57192
Review Report on MCOLN1 Target / Biomarker Content of Review Report on MCOLN1 Target / Biomarker
MCOLN1
Other Name(s): MSTP080 | Mucolipin-1 | transient receptor potential mucolipin 1 | TRPML1 | ML1 | MCLN1_HUMAN | Mucolipidin | mucolipin 1 | mucolipidin | MLIV | MST080 | TRPM-L1 | transient receptor potential channel mucolipin 1 | Mucolipin 1 | ML4 | transient receptor potential cation channel mucolipin subfamily member 1 | Mucolipin TRP cation channel 1 | TRP-ML1 | mucolipidosis type IV protein | MG-2 | mucolipin TRP cation channel 1 | Transient receptor potential channel mucolipin 1

MCOLN1: A Protein Implicated in Various Diseases

MCOLN1 (MSTP080) is a protein that is expressed in various tissues throughout the body, including the brain, lungs, heart, and gastrointestinal tract. It is a member of the Maxwell family of proteins, which includes a variety of biological Protein that plays an important role in the body. MCOLN1 plays an important role in biological processes such as cell signaling, cell proliferation, apoptosis and immune response.

Discovery and drug development of MCOLN1

MCOLN1 was originally discovered by American scientists in 1995. They found that MCOLN1 is a protein that is highly expressed in a variety of tumors. Since then, researchers have conducted in-depth studies on MCOLN1 and found that it is closely related to the occurrence and development of various diseases.

The relationship between MCOLN1 and tumors

MCOLN1 is closely related to the occurrence and development of various tumors. Studies have shown that the expression level of MCOLN1 is positively correlated with tumor invasion and metastasis capabilities. In addition, the expression level of MCOLN1 is also related to the biological processes of tumor invasion and metastasis, such as angiogenesis, fibrosis, tumor cell heterogeneity, etc.

MCOLN1鈥檚 relationship with the immune system

MCOLN1 is also closely related to the immune system. Research shows that MCOLN1 can regulate the activity and function of immune cells, thereby participating in the regulation of immune responses. In addition, MCOLN1 can also regulate inflammatory responses and participate in the regulation of inflammatory responses.

MCOLN1 functions and drug targets

MCOLN1 plays an important role in biological processes and is therefore considered a potential drug target. Currently, researchers are exploring the application of MCOLN1 in drug development. For example, some researchers are exploring whether MCOLN1 could serve as a drug target to treat certain tumors. In addition, MCOLN1 is also closely related to the occurrence and development of various diseases and is therefore considered an important biomarker.

Biological functions of MCOLN1

MCOLN1 is a protein expressed in multiple tissues, including brain, lungs, heart and gastrointestinal tract. It plays an important role in biological processes such as cell signaling, cell proliferation, apoptosis and immune response.

The role of MCOLN1 in cell signaling

MCOLN1 plays an important role in cell signaling. Studies have shown that MCOLN1 can bind to intracellular receptors, thereby regulating intracellular signaling. In addition, MCOLN1 can also affect cell signaling by regulating cell metabolism.

The role of MCOLN1 in cell proliferation

MCOLN1 plays an important role in cell proliferation. Studies have shown that MCOLN1 can participate in the S phase of the cell cycle, thereby promoting cell proliferation. In addition, MCOLN1 can also regulate cell apoptosis, thereby controlling cell growth and division.

The role of MCOLN1 in apoptosis

MCOLN1 plays an important role in apoptosis. Studies have shown that MCOLN1 can regulate intracellular apoptosis signaling and thus participate in cell apoptosis. In addition, MCOLN1 can also regulate cell survival and death, thereby controlling cell growth and division.

The role of MCOLN1 in immune responses

MCOLN1 plays an important role in immune response. Studies have shown that MCOLN1 can participate in the activation and function of immune cells, thereby regulating the regulation of immune responses. In addition, MCOLN1 can also regulate inflammatory responses and participate in the regulation of inflammatory responses.

Clinical applications of MCOLN1

MCOLN1 plays an important role in the onset and development of diseases such as tumors, immune system disorders, and neurological diseases. Therefore, MCOLN1 is considered a potential drug target. Currently, researchers are exploring the application of MCOLN1 in drug development. For example, some researchers are exploring whether MCOLN1 could serve as a drug target to treat certain tumors. In addition, MCOLN1 is also closely related to the occurrence and development of various diseases and is therefore considered an important biomarker.

Protein Name: Mucolipin TRP Cation Channel 1

Functions: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis (PubMed:11013137, PubMed:12459486, PubMed:15336987, PubMed:14749347, PubMed:29019983, PubMed:27623384). Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:15336987, PubMed:14749347, PubMed:25720963, PubMed:29019983, PubMed:27623384). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:25720963, PubMed:25733853, PubMed:27787197). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity)

The "MCOLN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MCOLN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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