Target Name: ZNF436
NCBI ID: G80818
Review Report on ZNF436 Target / Biomarker Content of Review Report on ZNF436 Target / Biomarker
ZNF436
Other Name(s): zinc finger protein 436 | KIAA1710 | DNA-binding protein | Zinc finger protein 436, transcript variant 1 | Zfp46 | Zinc finger protein 436 | ZN436_HUMAN | ZNF436 variant 1 | Zinc finger protein 436 (isoform 1) | ZNF

ZNF436: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of non-coding RNAs that play a crucial role in various cellular processes. ZNF436, a member of the ZNF gene family, is a ZFP that has been identified as a potential drug target and biomarker. In this article, we will explore ZNF436 and its potential applications in drug development.

Structure and Function

ZNF436 is a 21 kDa protein that consists of 206 amino acid residues. It has a characteristic ZNF-like domain, which is composed of a nucleotide-binding oligomerization (NBO) domain and a carboxy-terminal domain. The NBO domain is responsible for the protein's stability and functions as a scaffold. The carboxy-terminal domain is involved in protein-protein interactions and may contribute to ZNF436's stability.

Functional assays have shown that ZNF436 can interact with several protein partners, including the transcription factor ASXL1. ASXL1 is a key regulator of stem cell growth and is known to play a role in the development and maintenance of cancer. ZNF436 has been shown to enhance the transcriptional activity of ASXL1, suggesting that it may be a useful drug target for cancer treatment.

Drug Target Potential

The potential drug target for ZNF436 is its interaction with ASXL1. ASXL1 has been shown to play a role in various cellular processes, including cell growth, apoptosis, and inflammation. It is a known drug target for cancer, including lung cancer, and has been shown to have a negative impact on cancer cell survival. By targeting ASXL1, ZNF436 may be able to inhibit its activity and lead to the regression of cancer cells.

Biomarker Potential

ZNF436 has also been shown to serve as a potential biomarker for various diseases, including cancer. The expression of ZNF436 has been shown to be regulated in various diseases, including cancer. For example, high expression of ZNF436 has been shown to be associated with poor prognosis in breast cancer. Additionally, ZNF436 has been shown to be expressed in various types of cancer, including lung, colorectal, and ovarian cancer. These findings suggest that ZNF436 may be a useful biomarker for cancer diagnosis and treatment.

Conclusion

ZNF436 is a ZFP that has been shown to interact with ASXL1 and enhance its transcriptional activity. Its potential drug target status and biomarker potential make it an attractive candidate for further study. Further research into the mechanisms of ZNF436's drug action and its potential as a biomarker may lead to the development of new cancer therapies.

Protein Name: Zinc Finger Protein 436

Functions: May be a transcriptional repressor

The "ZNF436 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF436 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

ZNF436-AS1 | ZNF438 | ZNF439 | ZNF44 | ZNF440 | ZNF441 | ZNF442 | ZNF443 | ZNF444 | ZNF445 | ZNF446 | ZNF449 | ZNF45 | ZNF451 | ZNF454 | ZNF460 | ZNF461 | ZNF462 | ZNF467 | ZNF468 | ZNF469 | ZNF470 | ZNF471 | ZNF473 | ZNF473CR | ZNF479 | ZNF48 | ZNF480 | ZNF483 | ZNF484 | ZNF485 | ZNF486 | ZNF487 | ZNF488 | ZNF490 | ZNF491 | ZNF492 | ZNF493 | ZNF496 | ZNF497 | ZNF497-AS1 | ZNF500 | ZNF501 | ZNF502 | ZNF503 | ZNF503-AS1 | ZNF503-AS2 | ZNF506 | ZNF507 | ZNF510 | ZNF511 | ZNF512 | ZNF512B | ZNF513 | ZNF514 | ZNF516 | ZNF516-DT | ZNF517 | ZNF518A | ZNF518B | ZNF519 | ZNF519P3 | ZNF521 | ZNF524 | ZNF525 | ZNF526 | ZNF527 | ZNF528 | ZNF528-AS1 | ZNF529 | ZNF529-AS1 | ZNF530 | ZNF532 | ZNF534 | ZNF536 | ZNF540 | ZNF541 | ZNF542P | ZNF543 | ZNF544 | ZNF546 | ZNF547 | ZNF548 | ZNF549 | ZNF550 | ZNF551 | ZNF552 | ZNF554 | ZNF555 | ZNF556 | ZNF557 | ZNF558 | ZNF559 | ZNF559-ZNF177 | ZNF560 | ZNF561 | ZNF561-AS1 | ZNF562 | ZNF563 | ZNF564