Target Name: ZNF420
NCBI ID: G147923
Review Report on ZNF420 Target / Biomarker Content of Review Report on ZNF420 Target / Biomarker
ZNF420
Other Name(s): FLJ32191 | zinc finger protein 420 | Apak | Zinc finger protein 420 (isoform b) | Zinc finger protein 420 | ATM and p53-associated KZNF protein | Zinc finger protein 420, transcript variant 2 | ZN420_HUMAN | KRAB-type zinc-finger protein Apak | APAK | ZNF420 variant 2

ZNF420: A Potential Drug Target and Biomarker for Diseases

ZNF420 (FLJ32191) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the Zinc finger gene family (ZNF), which is known for the involvement of genetic disorders such as neurofibromatosis and cancer. ZNF420 has been shown to play a role in several cellular processes, including cell growth, differentiation, and survival.

One of the most significant functions of ZNF420 is its role in cell survival. Studies have shown that overexpression of ZNF420 can lead to the formation of cancerous tumors, suggesting that it may be a potential drug target for cancer therapies. Additionally, ZNF420 has been shown to play a role in the regulation of cell death, which is a critical process that helps maintain tissue homeostasis and prevent cellular damage.

Another function of ZNF420 is its role in cell differentiation. Studies have shown that ZNF420 can promote the transition of stem cells into functional neurons, which is a critical step in the development of neural circuits. This function may have implications for the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

In addition to its role in cell survival and differentiation, ZNF420 has also been shown to play a role in the regulation of gene expression. Studies have shown that ZNF420 can interact with other genes, including TGF-β1, to regulate the expression of target genes. This function may have implications for the regulation of cellular processes that are relevant to a wide range of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

Given the significance of ZNF420's role in several cellular processes, it is a promising target for drug development. Studies have shown that the drug erlotinib, which is a inhibitor of thetyrosine kinase (TK), can lead to the inhibition of ZNF420, which can lead to the inhibition of cell proliferation and survival. This suggests that ZNF420 may be a potential drug target for cancer therapies.

In addition to its potential as a drug target, ZNF420 is also a potential biomarker for several diseases. Studies have shown that the expression of ZNF420 is downregulated in a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders. This suggests that ZNF420 may be a potential biomarker for these diseases, and that its levels may be a useful diagnostic or therapeutic target.

Overall, ZNF420 is a protein that has significant implications for several cellular processes and has been shown to play a role in the development and progression of a wide range of diseases. Further research is needed to fully understand its role in these processes and to determine its potential as a drug target and biomarker.

Protein Name: Zinc Finger Protein 420

Functions: May be involved in transcriptional regulation

The "ZNF420 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF420 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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