Understanding UVSSA: A Non-Coding RNA Molecule Regulating Skin Physiology

Target Name: UVSSA

NCBI ID: G57654

UVSSA

Understanding UVSSA: A Non-Coding RNA Molecule Regulating Skin Physiology

UVSSA (UVSSA variant 1) is a non-coding RNA molecule that has been identified as a potential drug target or biomarker. It is a key regulator of gene expression in the ultraviolet-sensitive skin epithelium, which is the outermost layer of the skin. UVSSA plays a crucial role in the regulation of cell growth, differentiation, and damage caused by UV radiation.

Recent studies have shown that UVSSA is involved in a wide range of physiological processes in the skin, including cell growth, apoptosis (programmed cell death), angiogenesis (the formation of new blood vessels), and immune response. It is also involved in the regulation of cell-cell interactions, cell signaling pathways, and the production of extracellular matrix (ECM) proteins.

One of the key functions of UVSSA is its ability to regulate the expression of genes involved in cell growth and differentiation. UVSSA has been shown to play a role in the regulation of cell proliferation and the control of cell cycle progression. It is also involved in the regulation of cell adhesion, cell migration, and the formation of tissues and organs.

In addition to its role in cell regulation, UVSSA has also been shown to be involved in the regulation of cellular signaling pathways. It is a negative regulator of the TGF-β pathway, which is involved in the regulation of cell growth, differentiation, and the formation of tissues and organs. UVSSA has also been shown to play a role in the regulation of the Wnt pathway, which is involved in the regulation of cell growth, differentiation, and the formation of tissues and organs.

The UVSSA gene has also been shown to be involved in the regulation of ECM protein production. ECM proteins are involved in the formation of the extracellular matrix, which provides support and structure to cells and tissues. UVSSA has been shown to play a role in the regulation of the production of ECM proteins, including extracellular matrix (ECM) collagen.

UVSSA has also been shown to be involved in the regulation of skin immune response. The skin is the body's first line of defense against external threats, including UV radiation. UVSSA has been shown to play a role in the regulation of skin immune response, including the regulation of skin cell proliferation and the formation of immune cells.

In conclusion, UVSSA is a non-coding RNA molecule that is involved in a wide range of physiological processes in the skin. Its role in cell regulation, signaling pathways, and ECM protein production makes it a potential drug target or biomarker. Further research is needed to fully understand the role of UVSSA in skin physiology and its potential as a drug or biomarker.

Protein Name: UV Stimulated Scaffold Protein A

Functions: Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (PubMed:22466610, PubMed:22466611, PubMed:22466612). Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites (PubMed:22466611, PubMed:32142649). Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome (PubMed:22466611, PubMed:22466612). Also facilitates transfer of TFIIH to RNA polymerase II (PubMed:32142649). Not involved in processing oxidative damage (PubMed:22466612)

The "UVSSA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UVSSA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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