FBH1: The Research and Potential Applications of a Key Enzyme

Target Name: FBH1

NCBI ID: G84893

FBH1

FBH1: The Research and Potential Applications of a Key Enzyme

F-box DNA helicase 1 (FBH1) is a key enzyme that plays a critical role in the regulation of DNA replication and repair. It is a 26-kDa protein that is expressed in various cell types, including eukaryotes, bacteria, and archaea. FBH1 is a member of the F-box DNA binding protein family, which includes a variety of enzymes that share a common catalytic core.

FBH1 is involved in the process of DNA replication, specifically in the initiation of the replication process. It functions as a template to create a double helix in the 5'-end of a newly synthesized DNA strand. FBH1 uses its enzyme-like active site to recruit the necessary components for DNA replication, such as the primers that will be used to create a new double helix.

In addition to its role in DNA replication, FBH1 has also been shown to be involved in the regulation of gene expression. It has been shown to play a role in the regulation of gene expression by modifying the levels of chromatin accessibility in the nucleus. This is accomplished through a process called histone remodeling, in which FBH1 can add or remove histone tails to specific locations on the chromatin.

Another potential application of FBH1 is as a drug target. The FBH1 enzyme has been shown to be involved in the regulation of cell growth and division, and it is thought to play a role in the development of cancer. FBH1 has also been shown to be involved in the regulation of cell survival, and it is thought to be a potential therapeutic target for a variety of diseases.

FBH1 has also been shown to be involved in the regulation of inflammation. It has been shown to play a role in the regulation of inflammation by modifying the levels of cytokines in the cytosol. This is accomplished through a process called cytokine signaling, in which FBH1 can add or remove cytokines from the cytosol.

In conclusion, FBH1 is a key enzyme that is involved in the regulation of DNA replication, gene expression, cell growth and division, and inflammation. It is a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of FBH1 in these processes and to develop effective treatments.

Protein Name: F-box DNA Helicase 1

Functions: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578)

The "FBH1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FBH1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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