FBN1: A Protein Role in Heart Function and Drug Development (G2200)

Target Name: FBN1

NCBI ID: G2200

FBN1

FBN1: A Protein Role in Heart Function and Drug Development

FBN1, or fibrillin 1, is a protein that is expressed in the heart muscle and is known for its role in heart function. It is a key protein in the regulation of the heartbeat and is often used as a drug target or biomarker in the development of new treatments for heart disease.

FBN1 is a transmembrane protein that is made up of four structural domains: an extracellular domain, a transmembrane domain, an intracellular domain, and a C-terminal region. The extracellular domain is responsible for the protein's ability to interact with other cells and molecules, while the transmembrane domain is responsible for the protein's ability to span the cell membrane and interact with intracellular signaling pathways. The intracellular domain is responsible for the protein's ability to interact with other proteins inside the cell, and the C-terminal region is responsible for the protein's ability to interact with DNA and other proteins.

FBN1 is involved in many different processes that are important for heart function. One of the most well-known functions of FBN1 is its role in heart rate regulation. FBN1 is known to play a key role in the regulation of the heart's contractility, which is the ability of the heart muscle to pump blood throughout the body.

In addition to its role in heart rate regulation, FBN1 is also involved in the regulation of the heart's electrical activity. FBN1 is known to play a key role in the regulation of the heart's electrical activity, which is responsible for the heart's normal rhythm.

FBN1 is also involved in the regulation of the blood flow to the heart muscle. FBN1 is known to play a key role in the regulation of the blood flow to the heart muscle, which is important for maintaining the heart's proper functioning.

FBN1 is a protein that is expressed in the heart muscle and is involved in many different processes that are important for heart function. Its role in heart rate, electrical activity, and blood flow regulation makes FBN1 an attractive drug target or biomarker for the development of new treatments for heart disease.

Protein Name: Fibrillin 1

Functions: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support (PubMed:27026396). In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin (PubMed:27026396). In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles (PubMed:27026396). Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11 (PubMed:24039232). This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921)

The "FBN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FBN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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