PUS10: A Potential Drug Target for Immune and Inflammatory Diseases

Target Name: PUS10

NCBI ID: G150962

PUS10

PUS10: A Potential Drug Target for Immune and Inflammatory Diseases

PUS10 (PUS10_HUMAN) is a protein that is expressed in various tissues of the human body, including the placenta, spleen, liver, and kidneys. It is a member of the Pusin family, which includes proteins that are involved in the immune response and inflammation.

PUS10 is a 10-kDa protein that is expressed in the placenta, spleen, liver, and kidneys. It is a member of the Pusin family, which includes proteins that are involved in the immune response and inflammation. PUS10 is made up of 96 amino acid residues and has a calculated pI of 4.75.

One of the unique features of PUS10 is its ability to interact with the immune system. It has been shown to play a role in the regulation of immune cell function and has been shown to interact with a variety of immune molecules, including T cells, B cells, and natural killer cells.

In addition to its role in the immune system, PUS10 has also been shown to play a role in the regulation of inflammation. It has been shown to reduce inflammation in various tissues and has been shown to have anti-inflammatory effects.

PUS10 is also of interest as a potential drug target. Its ability to interact with immune molecules and its anti-inflammatory effects make it a promising target for the development of new treatments for a variety of diseases.

In conclusion, PUS10 is a protein that is expressed in various tissues of the human body and is involved in the immune response and inflammation. Its unique properties make it a promising target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of PUS10 in the immune system and its potential as a drug target.

Protein Name: Pseudouridine Synthase 10

Functions: Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm (PubMed:31819270, PubMed:33023933). In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs (PubMed:30530625, PubMed:31819270, PubMed:33023933). tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs (PubMed:30530625). Does not show tRNA pseudouridylate synthase activity in the nucleus (PubMed:33023933). In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity (PubMed:31819270). Binds pri-miRNAs (PubMed:31819270). Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage (PubMed:14527409, PubMed:19712588). Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (PubMed:19712588)

The "PUS10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PUS10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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