RBM14-RBM4: A Promising Drug Target / Biomarker (G100526737)
RBM14-RBM4: A Promising Drug Target / Biomarker
The molecule RBM14-RBM4 is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of RNA-binding proteins (RBP), which are known for their ability to interact with RNA molecules. Despite its importance in various cellular processes, little is known about RBM14-RBM4. In this article, we will explore the potential drug targets and biomarkers associated with RBM14-RBM4.
Potential Drug Targets
RBM14-RBM4 has been identified as a potential drug target due to its involvement in several cellular processes. One of the main targets of RBM14-RBM4 is the interaction between this protein and RNA molecules. This interaction allows RBM14-RBM4 to regulate the translation of RNA into protein, which is a critical process for cellular growth and development.
RBM14-RBM4 has been shown to play a role in the regulation of gene expression, specifically in the regulation of stem cell proliferation. In addition, RBM14-RBM4 has been shown to interact with microRNA (miRNA) molecules, which are small non-coding RNAs that play a critical role in post-transcriptional gene regulation. This interaction between RBM14-RBM4 and miRNA molecules suggests that RBM14-RBM4 may be a useful target for drugs that are designed to modulate miRNA function.
Another potential drug target for RBM14-RBM4 is its role in the regulation of cellular stress. RBM14-RBM4 has been shown to interact with stress-responsive genes, including the stress-responsive protein p53. This interaction suggests that RBM14-RBM4 may play a role in the regulation of cellular stress responses, which could make it a useful target for drugs that are designed to modulate stress responses.
Potential Biomarkers
In addition to its potential drug targets, RBM14-RBM4 may also be a useful biomarker for certain diseases. For example, RBM14-RBM4 has been shown to be expressed in the brains of individuals with Alzheimer's disease, which is a progressive neurodegenerative disorder that is characterized by the accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain.
In addition, RBM14-RBM4 has also been shown to be involved in the regulation of cellular processes that are important for brain development and function. For example, RBM14-RBM4 has been shown to play a role in the regulation of neuron-proximal synapse formation, which is a critical process for the development and function of neurons.
Conclusion
In conclusion, RBM14-RBM4 is a protein that has been shown to play a role in various cellular processes, including the regulation of gene expression, stress responses, and neuron-proximal synapse formation. As a result, RBM14-RBM4 has potential as a drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of RBM14-RBM4 in cellular processes and its potential as a drug and biomarker.
Protein Name: RBM14-RBM4 Readthrough
Functions: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728)
The "RBM14-RBM4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RBM14-RBM4 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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