Target Name: RBM20
NCBI ID: G282996
Review Report on RBM20 Target / Biomarker Content of Review Report on RBM20 Target / Biomarker
RBM20
Other Name(s): RNA-binding motif protein 20 | RNA-binding protein 20 | truncated RNA binding motif protein 20 | RNA binding motif protein 20 | RBM20_HUMAN | Probable RNA-binding protein 20 | probable RNA-binding protein 20

Overview of RNA-Binding Motif (RBM) Protein RBM20

RNA-binding motif (RBM) proteins are a family of non-protein coding RNA molecules that play a crucial role in various cellular processes. These proteins are known to interact with RNA molecules and are involved in the regulation of gene expression. One of the well-known RBM proteins is RBM20, which is a protein that is expressed in various tissues and cells and is known to play a role in the regulation of gene expression.

RBM20 is a 20-kDa protein that is composed of 151 amino acid residues. It has a characteristic RBM domain that is composed of a nucleotide-binding oligomerization (NBO) domain and a leucine-rich repeat (LRR) domain. The NBO domain is known for its ability to form a stable RNA-protein complex, while the LRR domain is involved in the formation of RNA secondary structures.

RBM20 is highly expressed in various tissues, including brain, heart, and muscle. It is also expressed in various cell types, including neurons, astrocytes, and macrophages. RBM20 is involved in the regulation of gene expression and has been shown to play a role in the development and progression of various diseases.

One of the most significant functions of RBM20 is its ability to interact with RNA molecules. It has been shown to interact with a wide range of RNA molecules, including mRNAs, tRNAs, and microRNAs. RBM20 has been shown to form stable RNA-protein complexes with various RNA molecules, including mRNAs, tRNAs, and miRNAs. These interactions play a critical role in the regulation of gene expression and are a key factor in the development of various diseases.

In addition to its role in gene expression, RBM20 is also involved in the regulation of RNA metabolism. It has been shown to play a role in the degradation of various classes of RNA, including miRNAs and smallRNAs. This function is important for the regulation of gene expression and the control of disease.

RBM20 is also involved in the regulation of cellular processes, including cell adhesion, migration, and the regulation of cell survival. It has been shown to play a role in the regulation of cell adhesion and migration, as well as the regulation of cell survival. This suggests that RBM20 may be involved in the development and progression of various diseases, including cancer.

In conclusion, RBM20 is a well-known protein that is involved in the regulation of gene expression and various cellular processes. Its function as a drug target or biomarker makes it an attractive target for research into the development and treatment of various diseases. Further research is needed to fully understand the role of RBM20 in disease and to develop effective treatments based on its properties.

Protein Name: RNA Binding Motif Protein 20

Functions: RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:22466703, PubMed:24960161, PubMed:27531932, PubMed:27496873, PubMed:26604136, PubMed:29895960, PubMed:30948719, PubMed:32840935, PubMed:35427468, PubMed:34732726). Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (PubMed:24960161, PubMed:30948719, PubMed:34732726). RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (PubMed:27531932, PubMed:30948719). RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (PubMed:27531932, PubMed:34732726). Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity)

The "RBM20 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RBM20 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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