Target Name: RBM24
NCBI ID: G221662
Review Report on RBM24 Target / Biomarker Content of Review Report on RBM24 Target / Biomarker
RBM24
Other Name(s): RNA-binding motif protein 24 | RNA binding motif protein 24 | RNA-binding region (RNP1, RRM) containing 6 | RNPC6 | RNA binding motif protein 24, transcript variant 1 | RNA-binding region-containing protein 6 | RNA-binding protein 24 (isoform 1) | RBM24_HUMAN | dJ259A10.1 | RBM24 variant 1 | RNA-binding protein 24

RBM24: A Non-Protein-Coding RNA Molecule with Potential as A Drug Target and Diagnostic Biomarker

RNA-binding motif (RBM) proteins are a family of non-protein coding RNAs that play a critical role in gene regulation. These small RNA molecules often have a specific structure that allows them to interact with specific target RNAs, such as mRNAs, and regulate the expression of those target RNAs. RBM24 is a RBM protein that has been identified as a potential drug target and may also be a diagnostic biomarker.

The RBM24 protein is a 24-kDa protein that is expressed in various tissues and cells. It is primarily localized to the nucleoplasm and is also found in the cytoplasm. RBM24 is a non-coding RNA molecule that contains 195 amino acid residues. It has a specific structure that includes a long terminal extension (LTE) that is involved in the formation of a stem-loop. This stem-loop is a common structural feature of RBM proteins and is involved in the formation of RNA-protein interactions.

RBM24 has been shown to play a critical role in the regulation of gene expression. Studies have shown that RBM24 can interact with various target RNAs and that it can regulate the translation of those target RNAs. This suggests that RBM24 may be a drug target for diseases that are characterized by the disruption of normal gene expression.

In addition to its role in gene regulation, RBM24 has also been shown to play a critical role in the development and progression of various diseases. For example, studies have shown that RBM24 is overexpressed in various cancer tissues and that it is involved in the regulation of cancer cell growth and survival. This suggests that RBM24 may be a useful biomarker for the diagnosis and treatment of cancer.

Furthermore, RBM24 has also been shown to play a critical role in the regulation of cellular processes that are important for maintaining cellular health. For example, RBM24 has been shown to play a role in the regulation of cell division and has been shown to interact with proteins that are involved in the maintenance of cellular stability. This suggests that RBM24 may be a useful target for diseases that are characterized by the disruption of normal cellular processes.

In conclusion, RBM24 is a non-protein coding RNA molecule that plays a critical role in the regulation of gene expression and the development and progression of various diseases. Its potential as a drug target and diagnostic biomarker makes it an attractive target for further study. Further research is needed to fully understand the role of RBM24 in disease progression and to develop effective treatments.

Protein Name: RNA Binding Motif Protein 24

Functions: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29358667, PubMed:29104163). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity). Together with RBM20, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity)

The "RBM24 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RBM24 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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