RBM15B: A RNA Binding Motif Protein with Potential Therapeutic Applications
RBM15B: A RNA Binding Motif Protein with Potential Therapeutic Applications
RNA binding motif (RBM) proteins are a family of non-protein coding RNAs that play a crucial role in various cellular processes. RBM15B, also known as RNA binding motif protein 15B, is one of the member of this family and is highly expressed in various tissues of the human body. It is characterized by a unique RBM domain that is responsible for its unique structure and function. This article will discuss the research on RBM15B, its potential drug target status, and its role in disease.
RBM15B is a 21-kDa protein that is expressed in various tissues of the human body, including brain, heart, liver, and pancreas. It is characterized by a unique RBM domain that is composed of a specific sequence of amino acids that is responsible for its unique structure and function. The RBM15B protein is composed of a single exon that is spliced multiple times to generate a 21-kDa protein.
One of the key features of RBM15B is its ability to bind to specific RNA targets. This is achieved by its RBM domain, which is composed of a specific sequence of amino acids that is responsible for creating a stable interaction with the target RNA. The RBM domain is composed of three beta-helices that are connected by a loop region. These beta-helices are responsible for creating a specific 3D structure that allows the RBM domain to bind to specific RNA targets.
Research has shown that RBM15B can interact with various RNA targets, includingmiRNA,siRNA,snRNA and also with some of the mRNAs. These interactions can lead to the regulation of various cellular processes, including cell growth, apoptosis, and translation of proteins.
RBM15B is also known as a potential drug target due to its unique structure and function. Its RBM domain has been shown to be involved in various cellular processes and its interacts with various RNA targets. Therefore, it is a promising target for small molecules, antibodies and other therapeutic agents.
In addition, RBM15B has also been shown to be involved in various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, studies have shown that RBM15B is involved in the regulation of cancer cell growth and progression, and that it may be a potential target for anti-cancer drugs. Similarly, RBM15B has also been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
In conclusion, RBM15B is a unique RNA binding protein that is characterized by its RBM domain and its ability to interact with various RNA targets. Its research has shown that it can be involved in various cellular processes and its potential drug target status makes it an attractive target for small molecules, antibodies and other therapeutic agents. Further studies are needed to fully understand the role of RBM15B in various diseases and to develop effective treatments.
Protein Name: RNA Binding Motif Protein 15B
Functions: RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518). Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation (PubMed:16129689). Inhibits pre-mRNA splicing (PubMed:21044963). Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 (PubMed:19586903)
The "RBM15B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RBM15B comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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RBM17 | RBM17P1 | RBM18 | RBM19 | RBM20 | RBM22 | RBM22P1 | RBM23 | RBM24 | RBM25 | RBM26 | RBM26-AS1 | RBM27 | RBM28 | RBM3 | RBM33 | RBM34 | RBM38 | RBM39 | RBM4 | RBM41 | RBM42 | RBM43 | RBM43P1 | RBM44 | RBM45 | RBM46 | RBM47 | RBM48 | RBM48P1 | RBM4B | RBM5 | RBM5-AS1 | RBM6 | RBM7 | RBM8A | RBMS1 | RBMS1P1 | RBMS2 | RBMS2P1 | RBMS3 | RBMS3-AS3 | RBMX | RBMX2 | RBMX2P1 | RBMXL1 | RBMXL2 | RBMXL3 | RBMY1A1 | RBMY1B | RBMY1D | RBMY1F | RBMY1J | RBMY2EP | RBMY2FP | RBP1 | RBP2 | RBP3 | RBP4 | RBP5 | RBP7 | RBPJ | RBPJL | RBPJP2 | RBPMS | RBPMS-AS1 | RBPMS2 | RBSN | RBX1 | RC3H1 | RC3H2 | RCAN1 | RCAN2 | RCAN3 | RCAN3AS | RCBTB1 | RCBTB2 | RCC1 | RCC1L | RCC2 | RCCD1 | RCE1 | RCHY1 | RCL1 | RCN1 | RCN1P2 | RCN2 | RCN3 | RCOR1 | RCOR2 | RCOR3 | RCSD1 | RCVRN | RD3 | RD3L | RDH10 | RDH11 | RDH12 | RDH13 | RDH14
