SLC1A1: A Protein Involved in Fluid Balance and Disease (G6505)

Target Name: SLC1A1

NCBI ID: G6505

SLC1A1

SLC1A1: A Protein Involved in Fluid Balance and Disease

SLC1A1 (also known as EAA3_HUMAN) is a gene that encodes a protein known as solute carrier family 1 member 1A (SLC1A1). The SLC1A1 protein is a transmembrane protein that is involved in the transport of various molecules across cell membranes. It is a key protein in the regulation of intracellular and extracellular fluid balance, and is expressed in many different tissues and cells in the body.

One of the unique features of SLC1A1 is its expression pattern. It is highly expressed in the brain, and is also found in other tissues and organs such as the heart, lungs, kidneys, and liver. It is also expressed in various cell types, including neurons, glial cells, and immune cells. This wide range of expression makes it an attractive drug target, as it suggests that SLC1A1 may be involved in a wide range of physiological processes.

SLC1A1 has also been shown to play a role in a number of diseases and disorders. For example, it is often expressed in individuals with Alzheimer's disease, and has been shown to be involved in the progression of this disease. Studies have also shown that SLC1A1 may be involved in the development of other neurological disorders, such as Parkinson's disease and Huntington's disease.

In addition to its potential involvement in neurological disorders, SLC1A1 has also been shown to be involved in a number of other biological processes. For example, it is involved in the regulation of ion and water transport in the body, which is important for maintaining the proper balance of fluids in the body. It is also involved in the regulation of pain perception, which may be relevant to the treatment of chronic pain.

Given the wide range of functions and the potential involvement in a number of diseases and disorders, SLC1A1 is an attractive drug target. Researchers are currently working to identify small molecules that can modulate SLC1A1 function and treat a variety of diseases. This field of research is in its infancy, and there is much to be learned about the biology and pharmacology of SLC1A1.

Protein Name: Solute Carrier Family 1 Member 1

Functions: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949, PubMed:33658209). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:33658209). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity)

The "SLC1A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SLC1A1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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