SMARCD1: Key Regulator of Cell Growth and Development (G6602)

Target Name: SMARCD1

NCBI ID: G6602

SMARCD1

Other Name(s): 60 kDa BRG-1/Brm-associated factor subunit A | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1, transcript variant 1 | OTTHUMP00000196567 | SMARCD1 variant 1 | BAF60A | Rsc6p | CRACD1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | chromatin remodeling complex BAF60A subunit | Chromatin remodeling complex BAF60A subunit | CSS11 | SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily D member 1 | mammalian chromatin remodeling complex BRG1-associated factor 60A | Swp73-like protein | Mammalian chromatin remodeling complex BRG1-associated factor 60A | SMRD1_HUMAN | OTTHUMP00000196568 | SWI/SNF complex 60 kDa subunit A | SWI/SNF complex 60 kDa subunit | BRG1-associated factor 60A | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

SMARCD1: Key Regulator of Cell Growth and Development

SMARCD1 (60 kDa BRG-1/Brm-associated factor subunit A) is a protein that is expressed in various tissues, including the brain, heart, and kidneys. It is a subunit of the BRG-1 (Browne-R specific transduction factor-1) gene, which encodes a protein that is involved in the regulation of cell growth, differentiation, and survival. SMARCD1 is one of the proteins that is associated with the BRG-1 gene.

SMARCD1 is a 60 kDa protein that is made up of 1,963 amino acids. It has a molecular weight of 21.9 kDa and a calculated pI of 6.8. SMARCD1 is found in various cellular organelles, including the cytoplasm, mitochondria, endoplasmic reticulum, and endosomal system . It is also found in the brain, where it is expressed in the cerebral cortical cortical and cerebellar regions.

SMARCD1 is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. It is a key regulator of the BRG-1 gene, which encodes a protein that is involved in the regulation of cell growth, differentiation, and survival. . SMARCD1 and BRG-1 work together to ensure that cells are able to survive and grow in the face of various cellular stressors, including changes in the level of oxygen, glucose, and nutrients.

SMARCD1 is also involved in the regulation of cellular interactions with other molecules, including the cytoskeleton, adhesion molecules, and signaling pathways. It is a member of the SMAR family of proteins, which includes SMARCD2, SMARCD3, and SMARCD4. These proteins are involved in the regulation of various cellular processes, including cell adhesion, migration, and survival.

SMARCD1 is also a potential drug target in the development of various diseases, including cancer. Studies have shown that SMARCD1 is highly expressed in various cancer tissues, including breast, ovarian, and prostate cancer. It is also involved in the regulation of cellular processes that are associated with cancer, including cell growth, differentiation, and survival.

SMARCD1 is also a potential biomarker for the diagnosis and prognosis of various diseases, including cancer. Studies have shown that SMARCD1 is highly expressed in various cancer tissues, including breast, ovarian, and prostate cancer. It is also involved in the regulation of cellular processes that are associated with cancer, including cell growth, differentiation, and survival. This suggests that SMARCD1 may be a useful biomarker for the diagnosis and prognosis of cancer.

In conclusion, SMARCD1 is a protein that is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. It is a key regulator of the BRG-1 gene and is highly expressed in various tissues, including the brain. SMARCD1 is also a potential drug target and biomarker for the diagnosis and prognosis of various diseases, including cancer. Further research is needed to fully understand the role of SMARCD1 in cellular processes and its potential as a drug target and biomarker.

Protein Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 1

Functions: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342). Interacts with AKIRIN2 (By similarity)

The "SMARCD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SMARCD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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