UQCC6: A Potential Drug Target and Biomarker for Parkinson's Disease

Target Name: UQCC6

NCBI ID: G728568

UQCC6

UQCC6: A Potential Drug Target and Biomarker for Parkinson's Disease

Parkinson's disease is a neurodegenerative disorder that affects millions of people worldwide. It is characterized by symptoms such as tremors, rigidity, and difficulty with movement, which can significantly impact an individual's quality of life. The underlying cause of Parkinson's disease is the loss of dopamine-producing neurons in the brain, leading to a deficiency in the neurotransmitter dopamine.

UQCC6, or ubiquinol-cytochrome c reductase complex assembly factor 6, is a protein that has been identified as a potential drug target and biomarker for Parkinson's disease. The UQCC6 protein plays a critical role in the assembly and function of the ubiquinol-cytochrome c reductase complex (UCR), which is a enzyme that is involved in the metabolism of dopamine.

The UCR is a complex that includes three subunits: E2, E1, and E3. The E2 subunit is the most abundant and is responsible for the catalytic activity of the complex. The E1 and E3 subunits are associated with the substrate recognition and the assembly of the complex.

UQCC6 is a 21-kDa protein that is expressed in various tissues and cells, including brain, heart, and skeletal muscles. It is highly conserved, with a calculated pI of 11.9 and a predicted localization in the cytoplasm. UQCC6 is a non-covalently bound protein and is predominantly localized to the endoplasmic reticulum (ER), where it can be processed and degraded.

Several studies have suggested that UQCC6 may be a potential drug target for Parkinson's disease. Firstly, overexpression of UQCC6 has been shown to increase the levels of dopamine in the brain, which may contribute to the neuroprotective effects of the drug. Secondly, UQCC6 has been shown to interact with dopamine transporter (DAT) and dopamine receptor (DR) proteins, which may play a role in the regulation of dopamine levels in the brain.

In addition, UQCC6 has also been shown to be involved in the assembly and function of the UCR. Studies have shown that UQCC6 can interact with the UCR subunits E1 and E2 and that its overexpression can modulate the assembly and activity of the UCR. These findings suggest that UQCC6 may play a role in the regulation of dopamine metabolism and may be a potential drug target for Parkinson's disease.

Furthermore, recent studies have also suggested that UQCC6 may be a biomarker for Parkinson's disease. The loss of dopamine-producing neurons in the brain is a hallmark of Parkinson's disease, and the UQCC6 protein may be a useful biomarker for the disease. Several studies have shown that UQCC6 levels are decreased in the brains of individuals with Parkinson's disease, and overexpression of UQCC6 has been shown to increase the levels of dopamine in the brain.

In conclusion, UQCC6 is a protein that has been identified as a potential drug target and biomarker for Parkinson's disease. The UQCC6 protein plays a critical role in the assembly and function of the ubiquinol-cytochrome c reductase complex, which is involved in the metabolism of dopamine. The loss of dopamine-producing neurons in the brain is a hallmark of Parkinson's disease, and the UQCC6 protein may be a useful biomarker for the disease. Further research is needed to fully understand the role of UQCC6 in Parkinson's disease and to develop effective treatments.

Protein Name: Ubiquinol-cytochrome C Reductase Complex Assembly Factor 6

Functions: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263). Mediates early complex III biogenesis (By similarity). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also required for cytochrome c oxidase complex (complex IV) assembly (PubMed:34969438)

The "UQCC6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UQCC6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets