Unveiling the Potential Drug Target UQCC3 (UPF0723 Protein C11orf83)

Target Name: UQCC3

NCBI ID: G790955

UQCC3

Unveiling the Potential Drug Target UQCC3 (UPF0723 Protein C11orf83)

Introduction

The discovery of new protein biomarkers has always been a cornerstone of medical research. These molecules have the potential to serve as targets for drugs, providing valuable insights into the underlying diseases. One such protein, UQCC3 (UPF0723), has recently gained significant attention due to its potential as a drug target. In this article, we will delve into the research on UQCC3, exploring its biology, function, and potential as a drug target.

Overview of UQCC3

UQCC3, also known as UPF0723, is a protein located in the C11 region of the human proteome. This protein is a key component of the cell membrane, forming part of the cell membrane association of protein C (C11) complex. UQCC3 plays a crucial role in maintaining the structural integrity of the cell membrane, allowing it to function as a barrier between the internal and external environments.

Expression and localization

UQCC3 is a highly expressed protein, with a prevalence of around 6% in human cell lines. Its expression is tissue-specific, with higher levels observed in heart, liver, and pancreas compared to other tissues. UQCC3 is predominantly localized to the endoplasmic reticulum (ER), a protein-rich organ responsible for the final sorting of proteins from the cytoplasm to the ER.

In addition to its ER localization, UQCC3 has been shown to be present in the plasma, indicating that it may also have potential as a biomarker. The association between UQCC3 and plasma proteins suggests that it may be a useful target for diagnostic tools in plasma- related diseases.

Dise alley role

The primary function of UQCC3 is to form part of the cell membrane association of protein C (C11) complex. This complex plays a crucial role in various cellular processes, including cell signaling, apoptosis, and inflammation. UQCC3 is involved in the regulation of several cellular processes, including:

1. Cell signaling: UQCC3 is involved in the regulation of T-cell signaling, which is crucial for the development and function of T-cells.

2. Apoptosis: UQCC3 is a key regulator of apoptosis, a process that is essential for the regulation of cell numbers and lifespan.

3. Inflammation: UQCC3 is involved in the regulation of inflammation, ensuring that it is controlled and limited.

Potential as a drug target

The potential drug target for UQCC3 is its involvement in various cellular processes that can be targeted by small molecules. Several studies have investigated the potential of drugs that can modulate UQCC3 activity, including inhibition of protein C activity and modulation of its expression levels.

One of the most promising avenues for drug development is the use of small molecules that can inhibit the activity of protein C. This class of drugs, known as C11 inhibitors, has been shown to be effective in various models of cancer, including inhibiting the growth of breast cancer cells and inhibiting the formation of blood-brain barriers.

Another approach to targeting UQCC3 is the use of small molecules that can modulate its expression levels. This can be achieved by either increasing or decreasing the levels of UQCC3 in cell lines or primary cells. This technique has been used to investigate the role of UQCC3 in various cellular processes, including cell signaling and apoptosis.

Conclusion

In conclusion, UQCC3 is a protein that has significant potential as a drug target due to its involvement in various cellular processes that can be targeted by small molecules. The regulation of protein C (C11) complex by UQCC3 plays a crucial role in maintaining the integrity of the cell membrane and is involved in various cellular processes, including cell signaling, apoptosis, and inflammation.

The potential of UQCC3 as a drug target is currently being investigated in various models of cancer, including inhibition of its activity

Protein Name: Ubiquinol-cytochrome C Reductase Complex Assembly Factor 3

Functions: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology

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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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