Unlocking The Potential of UPRTase: A Key Enzyme in DNA Damage Repair and Cellular Processes

Target Name: UPRT

NCBI ID: G139596

UPRT

Unlocking The Potential of UPRTase: A Key Enzyme in DNA Damage Repair and Cellular Processes

UPRT (UPRTase), also known as UPRT1 (UPRTase1), is a protein that is expressed in most tissues of the body. It is a key enzyme of the UPRT pathway, which is involved in the regulation of DNA damage repair. UPRTase is a strong candidate to be a drug target or biomarker due to its unique function and the potential it holds for the development of therapeutic approaches for various diseases.

The UPRT pathway is a complex molecular pathway that plays a crucial role in the regulation of DNA damage repair. It consists of several proteins, including UPRTase, UPRT, UPRT2, UPRT5, and UPRT6. These proteins work together to repair damaged DNA in the cells , ensuring that the genetic material is preserved and the cell can continue to function properly.

UPRTase is a key enzyme in the UPRT pathway that activates the pathway. It catalyzes the conversion of GDP (Guanosine Diphosphate) to GTP (Guanosine Triphosphate), which is a critical step in the DNA damage repair process. The UPRTase enzyme has a unique structure that allows it to interact with various protein partners, including the repair machinery and DNA-binding proteins.

One of the unique features of UPRTase is its role in the regulation of DNA double-strand breaks. Double-strand breaks are a common form of DNA damage that can occur during the repair process. UPRTase is involved in the recognition and repair of these breaks , ensuring that the genetic material is preserved.

In addition to its role in DNA damage repair, UPRTase has also been shown to play a key role in the regulation of cellular processes that are important for cell survival. For example, UPRTase has been shown to be involved in the regulation of cell cycle progression. , apoptosis (programmed cell death), and cell signaling.

Given its unique function and the potential it holds for the development of therapeutic approaches, UPRTase is a promising drug target or biomarker. Studies have shown that UPRTase is highly expressed in a variety of tumor tissues, including cancer, suggesting that it may be a useful target for cancer therapies.

Furthermore, UPRTase has also been shown to be involved in the regulation of inflammation and cellular signaling. shown to play a key role in the regulation of cellular signaling, including the regulation of cell proliferation and the establishment of cellular networks.

In conclusion, UPRTase is a protein that is expressed in most tissues of the body and plays a crucial role in the regulation of DNA damage repair. Its unique function and the potential it holds for the development of therapeutic approaches make it an attractive candidate for drug targeting. Further research is needed to fully understand the role of UPRTase in various cellular processes and to develop effective therapies based on its unique properties.

Protein Name: Uracil Phosphoribosyltransferase Homolog

The "UPRT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UPRT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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