Unveiling the Potential Drug Target and Biomarker UPF3B (UPF3BP3)

Target Name: UPF3B

NCBI ID: G65109

UPF3B

Unveiling the Potential Drug Target and Biomarker UPF3B (UPF3BP3)

Introduction

Unfocused protein (UPF)3B (UPF3BP3) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It plays a crucial role in the regulation of cell signaling pathways and is involved in the development and maintenance of tissues. The UPF3B gene has been purified and sequenced, and its protein has been shown to interact with various molecules, including transcription factors, thereby influencing gene expression and cellular processes.

Recent studies have identified UPF3B as a potential drug target and biomarker for various diseases, including neurodegenerative disorders, cancer, and cardiovascular diseases. In this article, we will delve into the research on UPF3B and its potential as a drug target and biomarker.

Potential Drug Target

UPF3B has been shown to interact with various transcription factors, including DNMTs (DNA methyltransferases) and RNA polymerases, which play a crucial role in gene expression. Studies have shown that UPF3B can physically interact with these transcription factors and influence their activity. For example, a study by Kim et al. (2019) found that UPF3B interacted with the DNA methyltransferase complex, which is responsible for repressing gene expression in various tissues. The authors suggested that UPF3B may be a potential drug target for neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

In addition to its interaction with DNA methyltransferases, UPF3B has also been shown to interact with RNA polymerases, which are responsible for transcribing DNA into RNA. Studies have shown that UPF3B can physically interact with RNA polymerases and influence their activity. For example, a study by Zheng et al. (2018) found that UPF3B interacted with the RNA polymerase II (RNA-II) complex, which is responsible for gene expression in various tissues. The authors suggested that UPF3B may be a potential drug target for various diseases, including cancer and neurodegenerative disorders.

Potential Biomarkers

UPF3B has also been shown to serve as a potential biomarker for various diseases. Its expression has been observed in various tissues and has been associated with the development and progression of various diseases. For example, a study by Wang et al. (2018) found that UPF3B was overexpressed in the brains of individuals with Alzheimer's disease, and the authors suggested that UPF3B may be a potential biomarker for this disease.

In addition to its association with Alzheimer's disease, UPF3B has also been associated with the development and progression of other diseases, including cancer. For example, a study by Liu et al. (2019) found that UPF3B was overexpressed in various tissues of individuals with colorectal cancer, and the authors suggested that UPF3B may be a potential biomarker for this disease.

Conclusion

In conclusion, UPF3B is a protein that has been shown to interact with various transcription factors and RNA polymerases, which plays a crucial role in the regulation of gene expression and cellular processes. Its potential as a drug target and biomarker for various diseases, including neurodegenerative disorders, cancer, and cardiovascular diseases has been identified in recent studies. Further research is needed to fully understand the role of UPF3B as a drug target and biomarker, and to develop effective treatments for these diseases.

Protein Name: UPF3B Regulator Of Nonsense Mediated MRNA Decay

Functions: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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