UPK2: A Protein Regulating Protein Degradation and Cell Signaling

Target Name: UPK2

NCBI ID: G7379

UPK2

UPK2: A Protein Regulating Protein Degradation and Cell Signaling

UPK2 (Ubiquitin-Proteasome Complex 2) is a protein that plays a crucial role in the regulation of protein degradation in the human body. It is a key component of the ubiquitin-proteasome complex (UPC), which is responsible for breaking down and removing damaged or unnecessary proteins from the body. Mutations in the UPK2 gene have been linked to a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a drug target or biomarker, UPK2 is a promising target for researchers to study and develop new treatments for these diseases.

The UPK2 protein is composed of 264 amino acids and has a calculated molecular weight of 31 kDa. It is located in the endoplasmic reticulum (ER) and is involved in the formation and stability of the UPC. The UPC is a complex protein that consists of a core of 26 amino acids called the N-terminus and a cytoplasmic tail. The N-terminus contains a region of 21 amino acids that includes the protein's catalytic active site and is involved in the formation of a covalent complex with other proteins. The cytoplasmic tail consists of 10 amino acids and is involved in the stability of the UPC.

The UPK2 gene is located on chromosome 11p36 and has been implicated in the development and progression of a variety of diseases. Studies have shown that mutations in the UPK2 gene are associated with the development of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that mutations in the UPK2 gene are associated with the development of colorectal cancer, lung cancer, and brain cancer.

In addition to its role in the regulation of protein degradation, UPK2 is also involved in the regulation of cell signaling processes. For example, studies have shown that UPK2 is involved in the regulation of the JAK/STAT signaling pathway, which is involved in the regulation of cell growth, differentiation, and survival. In addition, UPK2 is also involved in the regulation of the PI3K/AKT signaling pathway, which is involved in the regulation of cell signaling processes that are important for cell survival and growth.

As a drug target or biomarker, UPK2 is a promising target for researchers to study and develop new treatments for various diseases. For example, studies have shown that inhibiting the activity of UPK2 has been shown to be effective in treating cancer, neurodegenerative diseases, and autoimmune disorders. In addition, UPK2 has also been shown to be a potential biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In conclusion, UPK2 is a protein that plays a crucial role in the regulation of protein degradation and cell signaling processes. Its role in these processes makes it an attractive target for researchers to study and develop new treatments for various diseases. As a drug target or biomarker, UPK2 is a promising target for researchers to investigate and develop new treatments for cancer, neurodegenerative diseases, and autoimmune disorders.

Protein Name: Uroplakin 2

Functions: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity)

The "UPK2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UPK2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets