Target Name: ZNF45
NCBI ID: G7596
Review Report on ZNF45 Target / Biomarker Content of Review Report on ZNF45 Target / Biomarker
ZNF45
Other Name(s): Zinc finger protein 45 | Zinc finger protein 45 (a Kruppel-associated box (KRAB) domain polypeptide) | ZNF45_HUMAN | Zinc finger protein KOX5 | zinc finger protein 45 (a Kruppel-associated box (KRAB) domain polypeptide) | Zinc finger protein 13 | ZNF13 | KOX5 | zinc finger protein KOX5 | zinc finger protein 13 | BRC1744 | zinc finger protein 45

Structure and Function of ZNF45: A Potential Drug Target Or Biomarker

ZNF45, also known as zinc finger protein 45, is a protein that is expressed in nearly all eukaryotic cells, although at varying levels. It plays a variety of biological functions in cells, including regulating gene expression, DNA damage repair, cell cycle regulation, etc. In addition, ZNF45 is closely related to the occurrence and development of many diseases and is therefore considered a potential drug target or biomarker. This article will introduce in detail the structure, function, and potential value of ZNF45 in drug research and clinical applications.

1. Structure

ZNF45 is a zinc finger transcription factor with a length of approximately 300 amino acids. It consists of two main domains: N-terminal domain and C-terminal domain. The N-terminal domain includes a zinc finger, an N-terminal 伪-helix, an N-terminal 尾-sheet, and two N-terminal hydrophobic regions. The C-terminal domain includes a C-terminal 伪-helix, a C-terminal 尾-sheet, and a C-terminal hydrophobic region. In addition, the C-terminal domain of ZNF45 contains a zinc finger domain, which is composed of two cysteine 鈥嬧?媟esidues connected by a sulfur-sulfur bond.

2. Function

1. Regulate gene expression

ZNF45 plays an important role in regulating gene expression in eukaryotic cells. Research shows that ZNF45 can control gene expression by binding to DNA. It can bind to the promoter region of certain genes, thereby enhancing the expression of these genes. In addition, ZNF45 can also bind to the enhancer regions of certain genes, thereby inhibiting the expression of these genes.

2. DNA damage repair

ZNF45 also plays an important role in cellular DNA damage repair. Research shows that ZNF45 can bind to DNA and play a key role in the DNA damage repair process. ZNF45 can bind to repair factors on DNA to help DNA repair.

3. Cell cycle regulation

ZNF45 also plays an important role in cell cycle regulation. Research shows that ZNF45 can bind to certain proteins and thereby control the position of these proteins in the cell cycle. This helps control spindle formation and mitosis during the cell cycle.

4. Interactions with other molecules

ZNF45 can also interact with other molecules, such as RNA-binding proteins, DNA-binding proteins, etc. These interactions are also important for the function of ZNF45

Protein Name: Zinc Finger Protein 45

Functions: May be involved in transcriptional regulation

The "ZNF45 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF45 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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