NR1H3: A Potential Drug Target and Biomarker (G10062)

Target Name: NR1H3

NCBI ID: G10062

NR1H3

NR1H3: A Potential Drug Target and Biomarker

The nervous system is a complex and dynamic system that plays a crucial role in the regulation of various physiological processes in the body. One of the key proteins involved in this regulation is neurotransmitter release, which is critical for the transmission of signals between neurons. The neurotransmitter acetylcholine (ACh) is a well-known example of a neurotransmitter that plays a crucial role in memory and learning. However, the regulation of ACh release is also involved in a wide range of other physiological processes, including sensory perception, movement, and micturition. The neurotransmitter release is regulated by a complex cascade of intracellular signaling pathways, and the proteinNR1H3 plays a crucial role in this regulation.

NR1H3 is a protein that is expressed in many different tissues and cells in the body. It is highly conserved across species, and is highly expressed in the brain, heart, and testes.NR1H3 is involved in the regulation of a wide range of physiological processes, including neurotransmitter release, cell survival, and cell migration. It is also involved in the regulation of ion channels, which are critical for the flow of electrical current through cells.

One of the key functions of NR1H3 is its role in the regulation of neurotransmitter release.NR1H3 is involved in the regulation of the release of several neurotransmitters, including ACh, a neurotransmitter that is involved in memory and learning.NR1H3 is known to play a role in the regulation of ACh release by interacting with the proteinendoplasmic reticulum (ER) transmembrane protein (Transient receptor potential cation channel subfamily 4, TRPV4). This interaction between NR1H3 and TRPV4 allows for the regulation of ACh release by ER-associated signaling pathways.

In addition to its role in neurotransmitter release, NR1H3 is also involved in the regulation of cell survival and cell migration.NR1H3 has been shown to play a role in the regulation of cell survival by interacting with the proteinp53, a protein that is involved in the regulation of DNA damage repair.NR1H3 is known to promote the p53-mediated regulation of cell survival by activating the proteinp53 and increasing its levels in the cell.

NR1H3 is also involved in the regulation of cell migration.NR1H3 has been shown to play a role in the regulation of cell migration by interacting with the proteinFAK1.NR1H3 is known to promote the FAK1-mediated regulation of cell migration by activating the proteinFAK1 and increasing its levels in the cell.

NR1H3 is a protein that has been shown to play a critical role in the regulation of many physiological processes. Its functions include the regulation of neurotransmitter release, cell survival, and cell migration.NR1H3 is a potential drug target that could be targeted by small molecules to treat a wide range of diseases. Further research is needed to fully understand the role of NR1H3 in the regulation of physiological processes and its potential as a drug target.

Protein Name: Nuclear Receptor Subfamily 1 Group H Member 3

Functions: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity)

The "NR1H3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NR1H3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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