NRBP2: A Potential Cancer Drug Target and Biomarker (G340371)

Target Name: NRBP2

NCBI ID: G340371

NRBP2

NRBP2: A Potential Cancer Drug Target and Biomarker

The novel protein, named NRBP2 (Transformation-related gene 16), has been identified as a potential drug target or biomarker in the field of cancer.NRBP2 is a 21-kDa protein that is expressed in various tissues and cells, including the brain, pancreas, and gastrointestinal tract. It is a key regulator of the transforming growth factor (TGF-β) signaling pathway, which plays a crucial role in cell growth, differentiation, and survival.

The TGF-β signaling pathway is a well-established mechanism that promotes cancer growth and progression. Activated TGF-β signaling leads to the production of extracellular matrix (ECM) components, such as collagen, which contribute to the development of cancer invasive and metastatic phenotypes.NRBP2 has been shown to regulate the TGF-β pathway in various cell types, including cancer cells.

NRBP2 functions as a negative regulator of TGF-β signaling. It interacts with the TGF-β receptor and blocks the recruitment of TGF-β signaling components to the receptor, thereby inhibiting TGF-β signaling.NRBP2 is a critical regulator of cell growth and differentiation, as it can alter the balance between cell proliferation and differentiation.

NRBP2 is also involved in the regulation of cell survival. It has been shown to protect cancer cells from apoptosis, which is a critical checkpoint of cell survival that helps prevent the development of cancer.NRBP2-deficient mice have increased sensitivity to chemotherapy and have shorter lifespans compared to their wild-type counterparts.

NRBP2 is a potential drug target or biomarker due to its involvement in the TGF-β pathway and its functions as a negative regulator of cell growth and survival. Various studies have suggested that targeting NRBP2 may be a promising strategy for the development of cancer therapies.

NRBP2 as a drug target

NRBP2 is a promising drug target due to its involvement in the TGF-β pathway.TGF-β is a potent signaling molecule that plays a crucial role in the development and progression of cancer.NRBP2 has been shown to regulate the TGF-β pathway in various cell types, including cancer cells.

NRBP2 has been shown to inhibit the TGF-β receptor, which is a critical component of the TGF-β pathway.NRBP2 has been shown to block the recruitment of TGF-β signaling components to the receptor, thereby inhibiting TGF-β signaling. This suggests thatNRBP2 may be an effective target for cancer therapies that target the TGF-β pathway.

NRBP2 has also been shown to play a role in the regulation of cell survival. It has been shown to protect cancer cells from apoptosis, which is a critical checkpoint of cell survival that helps prevent the development of cancer.NRBP2-deficient mice have increased sensitivity to chemotherapy and have shorter lifespans compared to their wild-type counterparts.

NRBP2 as a biomarker

NRBP2 has also been suggested as a potential biomarker for cancer.NRBP2 is expressed in various tissues and cells, including the brain, pancreas, and gastrointestinal tract, making it a potential biomarker for cancer in these organs.

NRBP2 has been shown to be downregulated in various types of cancer, including breast, ovarian, and colorectal cancers.This suggests thatNRBP2 may be a potential biomarker for these cancers.NRBP2 has also been shown to be upregulated in various types of cancer, including lung and cervical cancers, which may be indicative of increased NRBP2 expression in these cancers.

Conclusion

In conclusion, NRBP2 is a novel protein that has been identified as a potential drug target or biomarker in the field of cancer.NRBP2 is involved in the regulation of the TGF-β pathway and has been shown to function

Protein Name: Nuclear Receptor Binding Protein 2

Functions: May regulate apoptosis of neural progenitor cells during their differentiation

The "NRBP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NRBP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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