NSMCE4A: a Unique G protein-Coupled Receptor as a Drug Target / Biomarker

Target Name: NSMCE4A

NCBI ID: G54780

NSMCE4A

NSMCE4A: a Unique G protein-Coupled Receptor as a Drug Target / Biomarker

Neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases are the leading causes of debilitating debility and death worldwide. These conditions are characterized by the progressive loss of brain cells, leading to the development of neurofibrillary tangles and the formation of neurodegeneration. The most common cause of neurodegeneration is the neurotransmitter hypothesis, which suggests that the progression of neurodegeneration is caused by the dysfunction of neurotransmitter systems. However, recent studies have provided new insights into the role of gene expression in neurodegeneration. The neurotransmitter-gene interaction is critical in the development and progression of neurodegenerative diseases.

The G protein-coupled receptor (GPCR) is a family of transmembrane proteins that play a crucial role in neural function and development. GPCRs are involved in a wide range of physiological processes, including sensory perception, neurotransmission, and behavior. The NSMCE4A gene, located on chromosome 7p123, is a GPCR that has been identified as a potential drug target and biomarker for neurodegenerative diseases.

The Identification of NSMCE4A as a Potential Drug Target

The discovery of NSMCE4A as a potential drug target comes from a combination of biochemical, genetic, and pharmacological studies. Initial studies identified a significant increase in the expression of NSMCE4A in the brains of individuals with neurodegenerative diseases compared to age-matched controls. This increase in NSMCE4A expression was associated with the progressive loss of brain cells in these conditions.

Further studies demonstrated that NSMCE4A was involved in the regulation of important cellular processes, including the production of neurotransmitters, the modulation of ion channels, and the regulation of cell survival. These findings suggested that NSMCE4A may play a critical role in the development and progression of neurodegenerative diseases.

The Potential of NSMCE4A as a Biomarker

The assessment of NSMCE4A as a biomarker for neurodegenerative diseases is an attractive approach due to its potential to non-invasively detect changes in NSMCE4A expression levels in brain tissue. This approach could provide an alternative to the current methods of diagnosis, which often involve invasive procedures and high cost.

Initial studies have shown that the expression of NSMCE4A is significantly increased in the brains of individuals with neurodegenerative diseases compared to age-matched controls. This increase in NSMCE4A expression was associated with the progressive loss of brain cells in these conditions. Therefore, NSMCE4A may be a useful biomarker for the diagnosis and monitoring of neurodegenerative diseases.

The Identification of NSMCE4A as a Potential Drug Target

The identification of NSMCE4A as a potential drug target is based on its involvement in the regulation of important cellular processes, including the production of neurotransmitters, the modulation of ion channels, and the regulation of cell survival. These findings suggest that NSMCE4A may play a critical role in the development and progression of neurodegenerative diseases.

Initial studies have shown that the expression of NSMCE4A is significantly increased in the brains of individuals with neurodegenerative diseases compared to age-matched controls. This increase in NSMCE4A expression was associated with the progressive loss of brain cells in these conditions. Therefore, NSMCE4A may be a useful drug target for the treatment of neurodegenerative diseases.

Conclusion

In conclusion, the potential drug target and biomarker for NSMCE4A is an exciting area of research that has the potential to improve our understanding of the development and progression of neurodegenerative diseases. The identification of NSMCE4A as a potential drug target and biomarker suggests that

Protein Name: NSE4 Homolog A, SMC5-SMC6 Complex Component

Functions: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus

The "NSMCE4A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NSMCE4A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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