A Potential Drug Target Protein Involved in DNA Replication and Gene Expression

Target Name: NT5C1A

NCBI ID: G84618

NT5C1A

A Potential Drug Target Protein Involved in DNA Replication and Gene Expression

Nucleotidase (NT5C1A), also known as 5'-nucleotidase or cytosolic NA, is a protein that plays a crucial role in the regulation of DNA replication in eukaryotic cells.NT5C1A is a 21-kDa protein that is expressed in most tissues of the body , including muscle, liver, and kidney. It is a member of the family of DNA polymerase II (2), which is responsible for the production of new DNA strands during DNA replication and repair.

Function and localization

NT5C1A is involved in the regulation of DNA replication by activating and repressing the activity of the DNA polymerase II. It does this by interacting with the enzyme, which is composed of multiple subunits that are involved in the movement of the DNA strand and the formation of a double helix.

In addition to its role in DNA replication, NT5C1A is also involved in the regulation of gene expression. It has been shown to play a role in the regulation of cell cycle progression, cell survival, and the response to chemotherapy drugs.

Drug targeting

NT5C1A is a protein that has been identified as a potential drug target due to its involvement in various cellular processes. One of the main reasons for its potential as a drug target is its involvement in DNA replication, which is a critical process for the survival of most organisms. Therefore, inhibitors of NT5C1A have been shown to be effective in various diseases, including cancer.

An inhibitor of NT5C1A, called A-2241, has been shown to be effective in inhibiting the growth and spread of cancer cells. A-2241 works by inhibiting the activity of NT5C1A, which results in the inhibition of DNA replication and the inhibition of cell growth.

Another potential drug target for NT5C1A is its role in the regulation of cell cycle progression. NT5C1A has been shown to play a role in the regulation of the G1 phase of the cell cycle, which is the stage of cell growth and preparation for cell division ( 7). Therefore, drugs that can inhibit the activity of NT5C1A during the G1 phase may be effective in treating various diseases, including cancer.

Conclusion

In conclusion, NT5C1A is a protein that is involved in various cellular processes, including DNA replication and gene expression. It has been shown to be a potential drug target due to its involvement in these processes. The inhibition of NT5C1A has been shown to be effective in treating various diseases, including cancer. Further research is needed to fully understand the role of NT5C1A in cellular processes and its potential as a drug target.

Protein Name: 5'-nucleotidase, Cytosolic IA

Functions: Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (PubMed:11133996, PubMed:7599155, PubMed:8967393, PubMed:34814800). AMP is the major substrate but can also hydrolyze dCMP and IMP (PubMed:11133996, PubMed:7599155, PubMed:8967393, PubMed:34814800)

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•   expression level;
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