NRG1: A Drug Target / Disease Biomarker (G3084)

Target Name: NRG1

NCBI ID: G3084

NRG1

NRG1: A Drug Target / Disease Biomarker

NRG1, short for Nucleotide Research Group 1, is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of cell proliferation and has been linked to a variety of diseases, including cancer. As a drug target or biomarker, NRG1 is of great interest to researchers because it can be targeted with small molecules or other therapeutic agents to treat or diagnose various diseases.

NRG1 was first identified in the late 1990s as a protein that was expressed in many tissues, including the brain, heart, and pancreas. It was found to be involved in the regulation of cell proliferation and differentiation, and it was suggested as a potential drug target for a variety of diseases. Since then, more research has been conducted on NRG1, and it has been shown to be involved in a number of important cellular processes.

One of the key functions of NRG1 is its role in cell proliferation. NRG1 is a transcription factor that regulates the expression of genes that are involved in cell growth and division. It has been shown to play a key role in the regulation of cell proliferation by promoting the growth of cells and the formation of new tissues. In addition, NRG1 has been shown to be involved in the regulation of cell differentiation, and it has been suggested as a potential drug target for a variety of diseases, including cancer.

Another function of NRG1 is its role in cell survival. NRG1 has been shown to play a key role in the regulation of cellular stress responses, and it has been shown to protect cells from the effects of stress and to regulate their ability to survive in the face of stress. This may be important for the treatment of diseases that are characterized by chronic stress, such as chronic pain or depression.

In addition to its role in cell proliferation and survival, NRG1 is also involved in the regulation of a variety of other cellular processes. For example, it has been shown to play a key role in the regulation of cell migration, and it has been suggested as a potential drug target for a variety of diseases, including cancer. In addition, NRG1 has been shown to play a key role in the regulation of the immune system, and it has been suggested as a potential drug target for a variety of diseases.

As a drug target or biomarker, NRG1 is of great interest to researchers because it can be targeted with small molecules or other therapeutic agents to treat or diagnose various diseases. For example, studies have shown that inhibiting the activity of NRG1 using small molecules has the potential to treat a variety of diseases, including cancer, depression, and chronic pain. In addition, NRG1 has also been shown to be a potential biomarker for a variety of diseases, including cancer.

In conclusion, NRG1 is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of cell proliferation and has been linked to a variety of diseases. As a drug target or biomarker, NRG1 is of great interest to researchers because it can be targeted with small molecules or other therapeutic agents to treat or diagnose various diseases. Further research is needed to fully understand the role of NRG1 in the regulation of cellular processes and its potential as a drug target or biomarker.

Protein Name: Neuregulin 1

Functions: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity)

The "NRG1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NRG1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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