NRARP: Key Component of The Notch Signaling Pathway (G441478)

Target Name: NRARP

NCBI ID: G441478

NRARP

Other Name(s): Notch-regulated ankyrin repeat-containing protein | NRARP_HUMAN | MGC61598 | NOTCH regulated ankyrin repeat protein

NRARP: Key Component of The Notch Signaling Pathway

Notch-regulated ankyrin repeat-containing protein (NRARP) is a protein that plays a crucial role in cell signaling pathways. It is a key component of the Notch signaling pathway, which is a well-established regulator of cell-to-cell and cell-tissue interactions, and is involved in the development, maintenance, and regulation of tissues and organs.

NRARP is a transmembrane protein that is expressed in a variety of tissues, including neural, muscle, and epithelial cells. It is characterized by a Notch-like extracellular domain that is involved in the formation of the Notch complex, a protein-protein interaction that plays a central role in the regulation of cell signaling pathways.

The Notch signaling pathway is a complex and highly conserved signaling pathway that is involved in the regulation of cell proliferation, differentiation, and survival. It is characterized by the presence of a Notch receptor, which is a transmembrane protein that is involved in the formation of the Notch complex. The Notch receptor is composed of two transmembrane subunits, Notch1 and Notch2, that are involved in the formation of the Notch complex.

The Notch complex is a protein-protein interaction that is formed by the interaction of the Notch receptor with various protein partners, including NRARP. NRARP is one of the protein partners that is interacting with the Notch receptor.

NRARP is a key component of the Notch complex because it plays a crucial role in the regulation of the Notch signaling pathway. It is involved in the formation of the Notch complex by interacting with the Notch receptor and in the regulation of the activity of the Notch receptor by interacting with the NOTCH1 subunit of the Notch receptor.

NRARP is also involved in the regulation of the Notch signaling pathway by interacting with the NOTCH2 subunit of the Notch receptor. It is known to play a role in the regulation of cell proliferation, differentiation, and survival by interacting with the NOTCH2 subunit and contributing to the negative regulation of NOTCH2 function.

In addition to its role in the Notch signaling pathway, NRARP is also involved in the regulation of various cellular processes, including cell signaling, cell adhesion, and cell migration. It is known to play a role in the regulation of T cell development and function by interacting with the PDGF-1 signaling pathway.

NRARP is also involved in the regulation of the development and maintenance of tissues and organs by playing a role in theNotch-regulated gene expression (NRG) pathway. This pathway is involved in the regulation of gene expression by the Notch receptor and is composed of multiple transcription factors, including NRARP.

NRARP is a protein that is involved in a variety of cellular processes and plays a crucial role in the regulation of the Notch signaling pathway. Its function as a drug target or biomarker makes it an attractive target for researchers to study and develop new treatments for various diseases. Further research is needed to fully understand the role of NRARP in the regulation of cellular processes and its potential as a drug target.

Protein Name: NOTCH Regulated Ankyrin Repeat Protein

Functions: Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity)

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