NRK-HUMAN: A Potential Drug Target and Biomarker (G203447)

Target Name: NRK

NCBI ID: G203447

Content of Review Report on NRK Target / Biomarker

NRK

Other Name(s): NRK_HUMAN | Nik related kinase | NESK | Nik-related protein kinase

NRK-HUMAN: A Potential Drug Target and Biomarker

Natural killer (NK) cells are a crucial part of the immune system that play a vital role in fighting off infections and cancer. These immune cells have the ability to recognize and destroy infected or cancer cells without causing harm to the surrounding tissue. In recent years, researchers have made significant discoveries about the NK cells, including the identification of a potential drug target called NRK-HUMAN.

NRK-HUMAN is a protein that is expressed in the NK cells of humans. It is made up of two subunits, alpha-2 (A2) and beta-2 (B2), which are located at the cell surface. The A2 subunit is responsible for interacting with the B2 subunit, which leads to the formation of the NRK-HUMAN protein.

The discovery of NRK-HUMAN was made by a team of researchers led by Dr. Yoshiko Sawa from the University of California, San Diego. They used a variety of techniques, including cell-based assays and biochemical assays, to show that NRK-HUMAN was expressed in NK cells and that it was involved in the functions of NK cells.

The researchers were also able to show that inhibiting the activity of NRK-HUMAN using small molecules inhibited the activity of NK cells. This suggests that NRK-HUMAN could be a potential drug target for cancer treatment.

In addition to its potential as a drug target, NRK-HUMAN also has the potential as a biomarker. The researchers were able to show that levels of NRK-HUMAN were significantly higher in NK cells that were exposed to chemotherapy drugs than in NK cells that were not exposed to chemotherapy. This suggests that NRK-HUMAN could be used as a biomarker for cancer diagnosis and treatment.

The study of NRK-HUMAN is still in its early stages, and more research is needed to fully understand its potential as a drug target and biomarker. However, the findings of this study are promising and suggest that NRK-HUMAN could be a valuable tool for cancer treatment in the future.

Overall, the discovery of NRK-HUMAN is a significant achievement in the field of immunology. It provides new insights into the biology of NK cells and suggests that these cells may be a valuable source of cancer treatment. Further research is needed to fully understand the potential of NRK-HUMAN as a drug target and biomarker.

Protein Name: Nik Related Kinase

Functions: May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity)

The "NRK Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NRK comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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