NRDE2: Key Enzyme in Cell Signaling and Disease Development (G55051)

Target Name: NRDE2

NCBI ID: G55051

NRDE2

NRDE2: Key Enzyme in Cell Signaling and Disease Development

NRDE2 (N-Acetyl-L-Leucine Hydroxyacetyltransferase 2) is a gene that encodes a protein in the human body. The protein produced by this gene is known as NRDE2, which is a key enzyme in the pathway of acetylation. Acetylation is a chemical modification that involves the addition of an acetyl group to a specific amino acid, and it plays a crucial role in various cellular processes in the body.

NRDE2 is highly expressed in many tissues of the human body, including the brain, heart, and muscle. It is also expressed in various types of cancer, which suggests that it may be involved in the development and progression of these diseases. Additionally,NRDE2 is highly expressed in the placenta, which suggests that it may be involved in fetal development and growth.

The role of NRDE2 in cellular signaling is still being fully understood. However, studies have shown that NRDE2 plays a crucial role in the regulation of various cellular processes, including cell growth, differentiation, and survival.

One of the key functions of NRDE2 is its role in the regulation of cell growth.NRDE2 has been shown to play a negative role in the growth of cancer cells. Studies have shown that inhibiting the activity of NRDE2 can significantly reduce the growth of cancer cells in a variety of models, including cell culture and animal models.

Another function of NRDE2 is its role in the regulation of cell differentiation.NRDE2 has been shown to play a critical role in the regulation of muscle cell differentiation and myogenesis. Studies have shown that inhibiting the activity of NRDE2 can significantly reduce the number of muscle cells that differentiate from stem cells in a variety of models.

NRDE2 has also been shown to play a crucial role in the regulation of cell survival. Studies have shown that inhibiting the activity of NRDE2 can significantly reduce the number of cancer cells that survive in a variety of models.

The potential clinical applications of NRDE2 are vast. As a drug target, NRDE2 may be used to treat a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Additionally, NRDE2 may be used as a biomarker to predict the outcomes of various therapies.

NRDE2 has also been shown to play a crucial role in the regulation of cellular signaling. Studies have shown that NRDE2 is involved in the regulation of various signaling pathways, including the PI3K/Akt signaling pathway, the TGF-β signaling pathway, and the NF-kappa-B signaling pathway.

TheNRDE2 gene has also been shown to be involved in the development of various diseases, including cancer. Studies have shown that individuals with certain genetic variations, such as those in the NRDE2 gene, are at an increased risk of developing certain types of cancer, including breast and ovarian cancer.

In conclusion, NRDE2 is a gene that encodes a protein that plays a crucial role in various cellular processes in the human body. The protein produced by this gene, NRDE2, has been shown to play a negative role in the regulation of cell growth, differentiation, and survival. The potential clinical applications of NRDE2 are vast, and it is an attractive drug target and biomarker for the development of various diseases.

Protein Name: NRDE-2, Necessary For RNA Interference, Domain Containing

Functions: Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation (PubMed:30842217). Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation (PubMed:30842217). Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome (PubMed:30842217). By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm (PubMed:30842217). U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis (PubMed:30538148). Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites (PubMed:30538148). Plays a role in DNA damage response (PubMed:29902117)

The "NRDE2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NRDE2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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