DDR1: A Potential Drug Target and Biomarker for Various Diseases

Target Name: DDR1

NCBI ID: G780

DDR1

DDR1: A Potential Drug Target and Biomarker for Various Diseases

DDR1 (CD167a), a protein that is expressed in various tissues throughout the body, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its functions and interactions with other proteins have been extensively studied, providing a foundation for the development of new therapeutic approaches.

DDR1 is a member of the adaptor protein family, which includes proteins that play a critical role in the intracellular signaling cascade. The adaptor protein family has been implicated in the regulation of various cellular processes, including cell adhesion, migration, and survival.

One of the well-established functions of DDR1 is its role in cell adhesion. DDR1 is involved in the formation of tight junctions, which are a type of cell-cell adhesion that is critical for maintaining tissue structure and function. DDR1 has been shown to play a crucial role in the formation of tight junctions in various tissues, including the brain and the placenta.

In addition to its role in cell adhesion, DDR1 has also been shown to be involved in the regulation of cell survival. DDR1 has been shown to play a critical role in the regulation of cell survival by promoting the expression of genes that are involved in cell stress response and apoptosis. This function of DDR1 has important implications for the development of new therapeutic approaches for diseases that are characterized by cellular dysfunction and stress.

DDR1 has also been implicated in the regulation of neurodegenerative diseases. As neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are characterized by the progressive loss of brain cells, it is important to identify new drug targets that can be targeted to treat these conditions. DDR1 has been shown to be involved in the regulation of neurodegenerative diseases, with studies suggesting that it may play a role in the development and progression of these conditions.

Furthermore, DDR1 has also been identified as a potential biomarker for various diseases, including cancer. The ability to detect and measure the expression of DDR1 has led to the development of new diagnostic tools for cancer, as well as new therapeutic approaches for cancer treatment.

In conclusion, DDR1 is a protein that has important roles in various cellular processes, including cell adhesion, survival, and neurodegenerative diseases. Its functions and interactions with other proteins have been extensively studied, providing a foundation for the development of new therapeutic approaches for a variety of diseases. Further research is needed to fully understand the role of DDR1 in these processes and to develop new treatments for diseases that are characterized by cellular dysfunction and stress.

Protein Name: Discoidin Domain Receptor Tyrosine Kinase 1

Functions: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11

The "DDR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DDR1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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