Vesicle Protein Sorting 26A: Potential Drug Targets Or Biomarkers

Target Name: VPS26A

NCBI ID: G9559

VPS26A

Vesicle Protein Sorting 26A: Potential Drug Targets Or Biomarkers

Vesicle protein sorting 26A (VPS26A) is a protein that is expressed in various cell types, including neurons, endothelial cells, and epithelial cells. It plays a crucial role in the sorting of proteins into different endoplasmic reticulum (ER) and endosomal vesicles, which are specialized structures for the transport and delivery of proteins to different cellular locations.

Recent studies have identified VPS26A as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its functions in protein sorting have also been implicated in a variety of cellular processes, including cell signaling, migration, and invasion.

One of the key functions of VPS26A is its role in the delivery of proteins to the ER, which is the primary site for protein synthesis and folding in the cell. In addition to its role in protein delivery, VPS26A is also involved in the regulation of endosomal vesicle formation and the composition of vesicles, as well as in the regulation of the trafficking of proteins to the ER and to the plasma membrane.

Recent studies have also suggested that VPS26A may be involved in the regulation of cellular processes that are important for the development and progression of cancer. For example, VPS26A has been shown to play a role in the regulation of cell cycle progression, and it has been implicated in the regulation of mitosis and apoptosis. In addition, VPS26A has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed in the body.

In addition to its role in the regulation of cellular processes, VPS26A has also been shown to be a potential drug target or biomarker for a variety of diseases. For example, VPS26A has been shown to be involved in the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In addition, VPS26A has also been shown to be involved in the development and progression of autoimmune disorders, including multiple sclerosis and rheumatoid arthritis.

Recent studies have also suggested that VPS26A may be involved in the regulation of inflammation and immune cell function. For example, VPS26A has been shown to play a role in the regulation of the production and function of immune cells, including T cells and B cells. In addition, VPS26A has also been shown to be involved in the regulation of inflammation, as it has been shown to play a role in the regulation of the recruitment and activation of immune cells.

In conclusion, Vesicle protein sorting 26A (VPS26A) is a protein that is involved in a variety of cellular processes, including protein delivery to the ER, endosomal vesicle formation, and regulation of endosomal vesicle traffic. In addition to its role in cellular processes, VPS26A has also been shown to be involved in the regulation of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, VPS26A is a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the functions of VPS26A and its potential as a drug target or biomarker.

Protein Name: VPS26 Retromer Complex Component A

Functions: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity)

The "VPS26A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VPS26A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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