VPS33B: A Late Endosome and Lysosome- Associated Protein with Potential as a Drug Target

Target Name: VPS33B

NCBI ID: G26276

VPS33B

VPS33B: A Late Endosome and Lysosome- Associated Protein with Potential as a Drug Target

Introduction

VPS33B (Vps33B late endosome and lysosome associated) is a protein that localizes to the endosome system and is involved in the delivery of various cellular organelles, including vesicles, to the cytosol. The endosome system is a complex network of organelles that play a crucial role in intracellular delivery and degradation of various macromolecules, including proteins, RNA, and vesicles. VPS33B is one of the key proteins that is involved in this process and has been identified as a potential drug target.

The Importance of VPS33B

VPS33B is a key protein that is involved in the delivery of vesicles to the cytosol, which is the site of intracellular degradation and recycling of various macromolecules. Vesicles are small organelles that wrap various bioactive molecules, including proteins, RNA, and small nucleic acids, and are involved in the delivery of these molecules to their final destinations in the cytosol for degradation or recycling.

VPS33B is a key component of the endosome system, which is a complex network of organelles that plays a crucial role in intracellular delivery and degradation of various macromolecules. The endosome system includes various components, including the endosome itself, the cisternal network, and the retroviral net, which are involved in the delivery and assembly of various vesicles and other intracellular structures.

VPS33B functions as a late endosome and lysosome- associated protein, which means that it is associated with both endosomes and lysosomes. Endosomes are small organelles that wrap various macromolecules, including proteins, RNA, and small nucleic acids, and are involved in the delivery of these molecules to their final destinations in the cytosol for degradation or recycling. Lysosomes are organelles that are involved in the degradation and recycling of various macromolecules, including proteins, RNA, and small nucleic acids.

VPS33B is involved in the delivery of various macromolecules to the cytosol via the endosome system. It functions as a late endosome and lysosome- associated protein, which means that it is associated with both endosomes and lysosomes. This helps to ensure that the macromolecules are delivered to the cytosol for degradation or recycling.

In addition to its role in intracellular delivery and degradation, VPS33B is also involved in the regulation of various cellular processes, including cell signaling, DNA replication, and protein synthesis. It is a key protein that is involved in the delivery of various macromolecules to the cytosol and is a potential drug target for various diseases.

Drug Target Potential

VPS33B is a protein that has been identified as a potential drug target due to its involvement in the delivery of various macromolecules to the cytosol. The delivery of macromolecules to the cytosol is a critical process that is involved in the regulation of various cellular processes, including cell signaling, DNA replication, and protein synthesis. As a result, VPS33B is a protein that has been shown to play a crucial role in the regulation of these processes and is a potential drug target for various diseases.

One of the key potential drug targets for VPS33B is the regulation of the delivery of macromolecules to the cytosol. Drugs that are able to inhibit

Protein Name: VPS33B Late Endosome And Lysosome Associated

Functions: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen (PubMed:28017832). Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity)

The "VPS33B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VPS33B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets