VPS11: A Potential Drug Target Or Biomarker (G55823)

Target Name: VPS11

NCBI ID: G55823

VPS11

VPS11: A Potential Drug Target Or Biomarker

VPS11 (VPS11_HUMAN) is a gene that has been identified as a potential drug target or biomarker for the treatment of various diseases, including cancer. The gene is located on chromosome 6 and encodes a protein known as VPS11.

VPS11 is a member of the voltage-dependent protein kinase (VDPK) family, which is a group of proteins that are involved in a variety of cellular processes, including cell signaling, metabolism, and stress response. The VDPK family has been implicated in the development and progression of many diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the unique features of VPS11 is its ability to form voltage-dependent conformational changes in response to changes in the electrical potential of the cell. This property allows the protein to interact with a variety of molecules and participate in a wide range of cellular processes.

In addition to its role in cellular signaling, VPS11 is also thought to play a key role in the regulation of gene expression. Studies have shown that VPS11 can interact with the RNA polymerase II (RNA-II) complex, which is responsible for transcribing DNA into RNA. This interaction may help to regulate the activity of RNA-II and influence the expression of genes involved in cellular processes such as cell growth, differentiation, and stress response.

The potential drug target status of VPS11 is based on several factors. First, the gene has been shown to be highly expressed in a variety of tissues and conditions, including cancer cells, which suggests that it may be a useful target for cancer treatments. Second, studies have shown that VPS11 can interact with a variety of small molecules, including drug compounds, which may suggest that it can be a useful biomarker for drug discovery.

Finally, the fact that VPS11 is involved in cellular signaling and gene regulation suggests that it may be a useful target for diseases that are characterized by misregulation of cellular signaling pathways. This is a common theme in many diseases, including cancer, where the failure of normal cellular signaling pathways can lead to the development of uncontrolled cell growth and the formation of tumors.

In conclusion, VPS11 is a promising drug target or biomarker for a variety of diseases. Its ability to form voltage-dependent conformational changes in response to changes in the electrical potential of the cell and its role in the regulation of gene expression make it an attractive candidate for drug development. Additionally, its expression in a variety of tissues and conditions suggests that it may be a useful biomarker for disease diagnosis and monitoring. Further research is needed to fully understand the potential of VPS11 as a drug target or biomarker.

Protein Name: VPS11 Core Subunit Of CORVET And HOPS Complexes

Functions: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995)

The "VPS11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VPS11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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