VPS33A: A Potential Drug Target and Biomarker (G65082)

Target Name: VPS33A

NCBI ID: G65082

VPS33A

VPS33A: A Potential Drug Target and Biomarker

Vacuolar protein sorting (VPS) is a protein that plays a crucial role in the intracellular delivery of various proteins. It is a highly conserved protein that is found in various organisms, including humans. One of the VPS proteins that has gained significant attention in recent years is VPS33A.

VPS33A is a 21 kDa protein that is expressed in various tissues and cells of the body. It is highly enriched in the vacuole, which is a specialized organ that plays a vital role in the intracellular delivery of various proteins.

Recent studies have shown that VPS33A is involved in various cellular processes, including the delivery of proteins to the vacuole and the regulation of intracellular signaling pathways. It is also involved in the development and progression of various diseases, including cancer.

Due to its involvement in various cellular processes, VPS33A has potential as a drug target or biomarker. Researchers are interested in developing drugs that can modulate the activity of VPS33A to treat various diseases.

One of the potential drug targets for VPS33A is the treatment of cancer. Cancer is a leading cause of death worldwide, and there is a significant need for new treatments that can effectively target this disease.

Studies have shown that VPS33A is involved in the delivery of proteins to the vacuole, which is a critical step in the development of cancer. In addition, VPS33A has been shown to play a role in the regulation of intracellular signaling pathways, which are often disrupted in cancer cells.

Research has also shown that VPS33A is involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and can lead to a wide range of symptoms, including cognitive decline and behavioral changes.

In addition to its involvement in cancer and neurodegenerative diseases, VPS33A has also been shown to be involved in the regulation of various physiological processes that are critical for human health. For example, VPS33A has been shown to play a role in the regulation of ion channels, which are responsible for the flow of electrical current through cells.

Ion channels are critical for the proper functioning of cells, and their regulation is critical for the development and maintenance of various physiological processes. VPS33A has been shown to play a role in the regulation of ion channels in various tissues and cells, which is important for maintaining the proper functioning of these channels.

In addition to its involvement in ion channels, VPS33A has also been shown to play a role in the regulation of various signaling pathways. These signaling pathways are responsible for the regulation of various cellular processes, including cell growth, differentiation, and inflammation.

VPS33A has been shown to play a role in the regulation of these signaling pathways by interacting with various signaling molecules. These interactions are important for the proper functioning of these signaling pathways and are critical for the development and maintenance of cellular processes.

In conclusion, VPS33A is a protein that has significant involvement in various cellular processes that are critical for human health. Its involvement in the delivery of proteins to the vacuole, the regulation of intracellular signaling pathways, and the regulation of ion channels makes it an attractive drug target or biomarker for the development of new treatments for cancer, neurodegenerative diseases, and other conditions. Further research is needed to fully understand the role of VPS33A in these processes and to develop effective treatments.

Protein Name: VPS33A Core Subunit Of CORVET And HOPS Complexes

Functions: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770)

The "VPS33A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VPS33A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets