Understanding VPS29: Regulation of Neural Activity and Disease

Target Name: VPS29

NCBI ID: G51699

VPS29

Understanding VPS29: Regulation of Neural Activity and Disease

VPS29 (Peptide-conjugated Protein 29) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is a member of the superfamily of proteins known as the Ca2+-dependent chloride channels, which are involved in the regulation of ion channels and signaling pathways that are critical for various physiological processes.

One of the unique features of VPS29 is its ability to form aggregates in the presence of certain ions, such as calcium. This aggregation is regulated by the protein Vps29 itself, which allows it to self-assemble into stable, discrete aggregates that are resistant to depolymerization.

The study of VPS29 has been primarily focused on its role in the regulation of calcium channels and its potential as a drug target. Several studies have shown that VPS29 plays a critical role in the regulation of neural excitability and synaptic plasticity, and that it is involved in the development and progression of a number of neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression.

In addition to its potential clinical applications, the study of VPS29 has also significant fundamental implications for our understanding of the underlying mechanisms of neural function and disease. The regulation of calcium channels by VPS29 is just one of many mechanisms that are involved in the control of neural activity, and its study has shed light on the complex interplay between ion channels, protein synthesis, and neurotransmission.

In conclusion, VPS29 is a protein that has important implications for our understanding of the regulation of neural activity and the development of disease. Further research is needed to fully understand its role in the regulation of calcium channels and its potential as a drug target.

Protein Name: VPS29 Retromer Complex Component

Functions: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922, PubMed:21725319, PubMed:23563491). Acts also as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (PubMed:24856514)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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