Targeting TEFM for Cancer and Metabolism (G79736)
Targeting TEFM for Cancer and Metabolism
TEFM (C17orf42), also known as ALDH11A2, is a gene that has been identified as a potential drug target or biomarker for several diseases. The gene is located on chromosome 17 and has been shown to be involved in the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism.
One of the key features of TEFM is its role in the development and progression of certain types of cancer. Studies have shown that TEFM mutations are frequently observed in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, altered expression of TEFM has also been observed in various types of cancer, including neuroendocrine and brain tumors.
Another potential drug target for TEFM is its role in the regulation of cell signaling. TEFM has been shown to play a role in the regulation of several signaling pathways, including the TGF-β pathway and the PI3K/Akt signaling pathway. These pathways are involved in various cellular processes, including cell growth, differentiation, and survival.
In addition to its role in cell signaling, TEFM is also involved in the regulation of DNA replication. Studies have shown that TEFM is involved in the regulation of DNA replication, including the loading of the DNA double helix into the nucleus and the regulation of the enzyme responsible for copying DNA.
Another potential drug target for TEFM is its role in the regulation of metabolism. TEFM has been shown to play a role in the regulation of various metabolic pathways, including cellular energy metabolism and metabolism of nutrients.
In conclusion, TEFM is a gene that has been identified as a potential drug target or biomarker for several diseases. Its role in the regulation of cell signaling, DNA replication, and metabolism makes it an attractive target for researchers to investigate further. Further studies are needed to determine the exact mechanisms by which TEFM functions as a drug target and to develop effective therapies for the treatment of diseases associated with TEFM mutations.
Protein Name: Transcription Elongation Factor, Mitochondrial
Functions: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery
The "TEFM Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TEFM comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
TEK | TEKT1 | TEKT2 | TEKT3 | TEKT4 | TEKT4P1 | TEKT4P2 | TEKT5 | TEKTIP1 | TELO2 | Telomerase holoenzyme complex | TEN1 | TEN1-CDK3 | Teneurin | TENM1 | TENM2 | TENM2-AS1 | TENM3 | TENM3-AS1 | TENM4 | TENT2 | TENT4A | TENT4B | TENT5A | TENT5B | TENT5C | TENT5C-DT | TENT5D | TEP1 | TEPP | TEPSIN | TERB1 | TERB2 | TERC | TERF1 | TERF1P3 | TERF2 | TERF2IP | TERLR1 | TERT | TES | TESC | TESK1 | TESK2 | TESMIN | TESPA1 | TET1 | TET2 | TET2-AS1 | TET3 | Tetraspanin | TEX10 | TEX101 | TEX11 | TEX12 | TEX13A | TEX13B | TEX13C | TEX14 | TEX15 | TEX19 | TEX2 | TEX21P | TEX22 | TEX26 | TEX261 | TEX264 | TEX28 | TEX29 | TEX30 | TEX33 | TEX35 | TEX36 | TEX36-AS1 | TEX37 | TEX38 | TEX41 | TEX43 | TEX44 | TEX45 | TEX46 | TEX47 | TEX48 | TEX49 | TEX50 | TEX52 | TEX53 | TEX55 | TEX56P | TEX9 | TF | TFAM | TFAMP1 | TFAP2A | TFAP2A-AS1 | TFAP2A-AS2 | TFAP2B | TFAP2C | TFAP2D | TFAP2E
