TERB2: Telomere Repeat Binding Protein 2 (G145645)
TERB2: Telomere Repeat Binding Protein 2
Telomere repeat binding bouquet formation protein 2 (TERB2) is a protein that plays a crucial role in the regulation of telomeres, which are repetitive DNA sequences at the ends of chromosomes that protect the ends of chromosomes from degradation and fusion. Telomeres are also involved in the aging process and are thought to be a potential drug target in the treatment of age-related diseases.
The Telomere Repeat-Binding Bouquet Formation Protein 2 (TERB2) is a protein that belongs to the TERB2 family, which is known for its role in regulating telomeres. TERB2 is a 21-kDa protein that is expressed in various tissues and cells of the body . It is highly conserved, with a calculated pI of 11.0 and a predicted localization in the cytoplasm.
The function of TERB2 is to regulate telomeres by binding to their terminal repeats. Telomeres are composed of a repeated sequence of DNA that is flanked by a variable number of repetitive units, which can include alphahelices, betahelices, and loops. These repetitive units are held together by a variety of interactions, including base-pairing, hydrogen bonding, and salt bridges.
TERB2 is known to interact with the terminal ends of telomeres and to regulate the dynamics of telomere repeat length. It does this by binding to the alphahelices and betahelices that are present at the ends of telomeres. This binding is thought to alter the stability of the telomere-repeat complex and to regulate the length of telomeres.
In addition to its role in regulating telomeres, TERB2 has also been shown to play a role in a variety of cellular processes. For example, it has been shown to be involved in the regulation of cell cycle progression, and in the establishment of tissue culture confidences. It has also been shown to be involved in the regulation of cell adhesion, and in the development of cancer.
Given its role in regulating telomeres and its potential involvement in a variety of cellular processes, TERB2 is a promising drug target. Researchers are currently working to identify small molecules that can inhibit TERB2's activity and to study its potential clinical applications. For example, some researchers are studying the potential of small molecules that can inhibit TERB2's activity in order to treat age-related diseases, such as cancer, heart disease, and neurodegenerative diseases.
In conclusion, Telomere repeat binding bouquet formation protein 2 (TERB2) is a protein that plays a crucial role in the regulation of telomeres. It is highly conserved and has been shown to interact with the terminal ends of telomeres and to regulate the length of telomeres . TERB2 is a potential drug target and is currently being studied in order to identify small molecules that can inhibit its activity and to study its potential clinical applications.
Protein Name: Telomere Repeat Binding Bouquet Formation Protein 2
Functions: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA
The "TERB2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TERB2 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
TERC | TERF1 | TERF1P3 | TERF2 | TERF2IP | TERLR1 | TERT | TES | TESC | TESK1 | TESK2 | TESMIN | TESPA1 | TET1 | TET2 | TET2-AS1 | TET3 | Tetraspanin | TEX10 | TEX101 | TEX11 | TEX12 | TEX13A | TEX13B | TEX13C | TEX14 | TEX15 | TEX19 | TEX2 | TEX21P | TEX22 | TEX26 | TEX261 | TEX264 | TEX28 | TEX29 | TEX30 | TEX33 | TEX35 | TEX36 | TEX36-AS1 | TEX37 | TEX38 | TEX41 | TEX43 | TEX44 | TEX45 | TEX46 | TEX47 | TEX48 | TEX49 | TEX50 | TEX52 | TEX53 | TEX55 | TEX56P | TEX9 | TF | TFAM | TFAMP1 | TFAP2A | TFAP2A-AS1 | TFAP2A-AS2 | TFAP2B | TFAP2C | TFAP2D | TFAP2E | TFAP4 | TFB1M | TFB2M | TFCP2 | TFCP2L1 | TFDP1 | TFDP1P2 | TFDP2 | TFDP3 | TFE3 | TFEB | TFEC | TFF1 | TFF2 | TFF3 | TFG | TFIID Basal Transcription Factor Complex | TFIIIC2 complex | TFIP11 | TFIP11-DT | TFPI | TFPI2 | TFPT | TFR2 | TFRC | TG | TGDS | TGFA | TGFA-IT1 | TGFB1 | TGFB1I1 | TGFB2 | TGFB2-AS1
