CASP14: A Protein Potential Drug Target Or Biomarker (G23581)

Target Name: CASP14

NCBI ID: G23581

CASP14

CASP14: A Protein Potential Drug Target Or Biomarker

CASP14, or Caspase-14 subunit p8, is a protein that is expressed in a variety of cell types, including neurons, muscle cells, and immune cells. It is a key player in the caspase family of proteins, which are involved in the regulation of cell death and apoptosis. In recent years, research has suggested that CASP14 may be a drug target or biomarker, with potential applications in a range of therapeutic areas.

At its core, CASP14 is a 14-kDa protein that is expressed in a variety of tissues and cell types. It is composed of a catalytic subunit and a regulatory subunit, which is responsible for regulating the activity of the catalytic subunit. The catalytic subunit of CASP14 contains a critical active site that is involved in the regulation of cell death and apoptosis.

One of the key functions of CASP14 is its role in cell death, which is a critical aspect of cellular homeostasis. When a cell is faced with an opportunity or threat that requires it to die, the cell goes through a process of apoptosis, which is a controlled form of cell death. During this process, CASP14 is involved in the regulation of the caspase-34 complex, which is responsible for executing the apoptotic program.

In addition to its role in cell death, CASP14 is also involved in the regulation of cell growth and differentiation. It has been shown to play a role in the regulation of neurogenesis, the process by which new neurons are produced in the brain, and in the regulation of muscle cell function.

Given its involvement in a range of cellular processes, it is not surprising that CASP14 has been suggested as a potential drug target or biomarker. Studies have shown that inhibitors of CASP14 have been shown to be effective in a range of therapeutic applications, including the treatment of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

In addition to its potential therapeutic applications, CASP14 has also been shown to be a useful biomarker for a range of diseases. For example, it has been used as a biomarker for neurodegenerative diseases, including Alzheimer's disease, and for cancer, including breast and ovarian cancer.

The potential applications of CASP14 are vast and continue to be explored by researchers. For example, studies are being conducted to investigate the use of CASP14 inhibitors as a potential treatment for a range of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Additionally, researchers are exploring the use of CASP14 as a potential biomarker for cancer, including breast and ovarian cancer.

In conclusion, CASP14 is a protein that is involved in a range of cellular processes, including cell death and cell growth. It has been suggested as a potential drug target or biomarker, with potential applications in a range of therapeutic areas, including neurodegenerative diseases and cancer. Further research is needed to fully understand the role of CASP14 in these processes and to explore its potential as a therapeutic intervention.

Protein Name: Caspase 14

Functions: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736)

The "CASP14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CASP14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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