Histone H4: A Protein with Multiple Functions (G8364)

Target Name: H4C3

NCBI ID: G8364

H4C3

Other Name(s): Histone H4 | DJ221C16.1 | histone cluster 1, H4c | H4C14 | translation initiation factor IF-2-like | H4 histone family, member G | TEVANED1 | H4C8 | histone cluster 1 H4 family member c | H4_HUMAN | H4C12 | H4C11 | H4C9 | H4 clustered histone 3 | dJ221C16.1 | H4FG | H4/g | H4C5 | H4C6 | H4C16 | H4C15 | H4C1 | histone 1, H4c | H4C4 | H4C13 | H4C2 | HIST1H4C | H4-16

Histone H4: A Protein with Multiple Functions

Histone H4 (H4) is a protein that plays a critical role in the regulation of gene expression and cell signaling. It is a key component of histones, which are small, positively charged proteins that make up the nucleosome, the basic unit of chromatin. Histones help to keep the nuclear genome organized and compact, and they play a crucial role in regulating the expression of genes.

One of the unique features of histones is their ability to interact with other proteins. H4 is one of the most well-studied histones, and it has been shown to play a role in many different cellular processes, including cell signaling, DNA replication, and gene expression.

One of the key functions of H4 is its ability to interact with the protein tyrosine kinase (TK). TK is a family of transmembrane proteins that play a key role in cell signaling, and it is activated by various signaling molecules, including histones. H4 has been shown to interact with TK and to play a role in regulating TK activity.

Another function of H4 is its role in the regulation of gene expression. Histones can interact with the transcription factors, which are proteins that bind to specific DNA sequences and help to regulate gene expression. H4 has been shown to interact with several transcription factors, including the nuclear factor of activated T cells (NFAT), which plays a role in regulating the expression of genes involved in cell signaling and inflammation.

H4 is also involved in the regulation of DNA replication. During DNA replication, the double helix is replicated in two separate copies, and each copy is then separated and used to create a new double helix. H4 is involved in the regulation of this process, and it has been shown to play a role in ensuring that the DNA replication machinery is working correctly.

In addition to its role in regulating gene expression and DNA replication, H4 is also involved in the regulation of cell signaling. It has been shown to play a role in the regulation of cell signaling pathways that are involved in cell growth, differentiation, and inflammation.

Overall, H4 is a protein that has critical roles in several cellular processes. Its ability to interact with other proteins and to regulate gene expression, DNA replication, and cell signaling makes it an attractive target for drug development. There is a growing body of research that has identified potential drug candidates that can inhibit H4 activity, and these drugs may have a variety of potential therapeutic applications.

Protein Name: H4 Clustered Histone 3

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

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•   general information;
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•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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