Unlocking the Potential of CALN1: A Calcium-Binding Protein with High-Impact Theoretical and Practical Significance

Target Name: CALN1

NCBI ID: G83698

CALN1

Unlocking the Potential of CALN1: A Calcium-Binding Protein with High-Impact Theoretical and Practical Significance

Introduction

Calcium-binding proteins (CBP) are a diverse family of proteins that play a crucial role in various physiological processes, including cell signaling, cytoskeletal organization, and chromatin regulation. One of the most well-known CBPs is calcium-binding protein 8 (CALN1 ), which is a protein that has been identified as a potential drug target and biomarker. In this article, we will explore the theoretical and practical significance of CALN1 and its potential as a drug target.

Theoretical Significance

CALN1 is a 21-kDa protein that is expressed in various tissues, including muscle, heart, brain, and pancreas. It is highly calcium-bound and has been shown to play a critical role in regulating calcium homeostasis. The protein is composed of a unique N-terminal domain, a middle domain, and a C-terminal domain. The N-terminal domain contains a nucleotide-binding oligomerization domain (NBO), which is responsible for the protein's calcium binding. The middle domain contains a unique structural domain , which is involved in the protein's stability and functions as a scaffold. The C-terminal domain contains a carboxy-terminal domain (CTD) that is involved in the protein's stability and functions as a receptor for interacting proteins.

Recent studies have provided significant evidence that CALN1 plays a critical role in various physiological processes. For instance, CALN1 has been shown to play a crucial role in regulating muscle contractions and cardiac function. In addition, the protein has been shown to play a critical role in the regulation of pancreatic function, including the production of insulin.

Practical Significance

CALN1 has also been identified as a potential drug target and biomarker. The high-impact of the protein makes it an attractive target for small molecule inhibitors, genetic modifiers, or biochemical approaches. The protein is also a good candidate for diagnostic tools, as changes in the level of the protein can indicate alterations in calcium homeostasis, which can be relevant for various diseases.

CALN1 has been shown to interact with numerous proteins, including the protein encoded by the SNORD2 gene. This interaction suggests that the protein may play a critical role in the regulation of various physiological processes, including muscle and cardiac function. In addition, the protein has been shown to interact with the protein encoded by the PDGF2 gene, which is involved in cell signaling.

Conclusion

In conclusion, the theoretical and practical significance of CALN1 makes it an attractive target for small molecule inhibitors, genetic modifiers, or biochemical approaches. The protein's role in regulating calcium homeostasis and its interactions with numerous proteins make it a promising candidate for drug targets or biomarkers . Further research is needed to fully understand the protein's function and its potential as a drug target or biomarker.

Protein Name: Calneuron 1

Functions: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning

The "CALN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CALN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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