Target Name: MCM8
NCBI ID: G84515
Review Report on MCM8 Target / Biomarker Content of Review Report on MCM8 Target / Biomarker
MCM8
Other Name(s): REC homolog | DNA helicase MCM8 (isoform 2) | MGC119522 | minichromosome maintenance complex component 8 | Minichromosome maintenance 8 | Minichromosome maintenance 8 homologous recombination repair factor, transcript variant 2 | Minichromosome Maintenance Protein 8 (MCM8) | Minichromosome maintenance 8 homologous recombination repair factor, transcript variant 1 | MCM8_HUMAN | MGC4816 | MGC12866 | MCM8 variant 1 | MGC119523 | DNA helicase MCM8 (isoform 1) | Minichromosome maintenance complex component 8 | minichromosome maintenance 8 homologous recombination repair factor | OTTHUMP00000030218 | DNA replication licensing factor MCM8 | dJ967N21.5 | C20orf154 | MCM8 variant 2 | OTTHUMP00000030217 | DNA helicase MCM8 | POF10 | REC | MCM8 minichromosome maintenance deficient 8

MCM8: A Key Regulator of Microtubule and Actin Filament Networks

MCM8, also known as REC homolog, is a gene that encodes a protein known as MCM8. The MCM8 protein is a key regulator of the microtubule network, which is a complex of filaments that organize and transport cells in various organisms. MCM8 plays a crucial role in the proper functioning of mitotic spindles, which are essential for cell division.

MCM8 is also involved in the regulation of the actin filament network, which is responsible for maintaining the shape and stability of the cell. It helps to keep the cell's cytoskeleton in check, ensuring that it remains organized and functional. MCM8 is also responsible for the regulation of the distribution of organelles within the cell, ensuring that they are properly distributed and that the cell is able to carry out its various functions efficiently.

MCM8 is a protein that is expressed in many different organisms, including bacteria, archaea, and eukaryotes. It is highly conserved across different species, which suggests that it is an important protein that plays a fundamental role in the functioning of all living organisms.

One of the key functions of MCM8 is its role in the regulation of the microtubule network. MCM8 is a key regulator of the assembly and disassembly of microtubules, which are composed of a protein called tubulin and a protein called microtubule protein. These proteins work together to form a protein structure that is essential for the proper functioning of the microtubule network.

MCM8 helps to regulate the assembly and disassembly of microtubules by playing a role in the regulation of the critical protein called microtubule-associated protein 2 (MAP2). MAP2 is a protein that is involved in the regulation of microtubule dynamics, and it is thought to play a key role in the assembly and disassembly of microtubules. MCM8 helps to regulate the activity of MAP2 by interacting with it and influencing its stability.

MCM8 is also involved in the regulation of the distribution of organelles within the cell. It helps to keep the cytoskeleton organized and ensure that the different organelles are properly distributed throughout the cell. This is important for the proper functioning of the cell, as the cytoskeleton helps to maintain the cell's shape and stability.

MCM8 is also involved in the regulation of cell division. It helps to ensure that the cell division process is properly regulated, which is essential for the growth and development of all living organisms. MCM8 plays a role in the regulation of the distribution of organelles during the G1 phase of cell division, when the cell prepares for cell division.

In addition to its role in the regulation of the microtubule network, MCM8 is also involved in the regulation of the actin filament network. It helps to keep the actin filament network organized and ensure that the actin filaments are properly distributed throughout the cell. This is important for the proper functioning of the cell, as the actin filament network helps to maintain the cell's shape and stability.

MCM8 is a protein that is highly conserved across different species. This suggests that it is an important protein that plays a fundamental role in the functioning of all living organisms. It is also a potential drug target, as the regulation of the microtubule network and the actin filament network are important targets for many different diseases.

In conclusion, MCM8 is a key regulator of the microtubule network and the actin filament network. It is highly conserved across different species and plays a crucial role in the proper functioning of many different organisms. As a potential drug target, MCM8 is a promising target for the study of a wide range of diseases. Further research is needed to fully understand the role of MCM8 in the

Protein Name: Minichromosome Maintenance 8 Homologous Recombination Repair Factor

Functions: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093)

The "MCM8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MCM8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

MCM8-MCM9 complex | MCM9 | MCMBP | MCMDC2 | MCOLN1 | MCOLN2 | MCOLN3 | MCPH1 | MCPH1-AS1 | MCPH1-DT | MCRIP1 | MCRIP2 | MCRS1 | MCTP1 | MCTP2 | MCTS1 | MCTS2 | MCU | MCUB | MCUR1 | MDC1 | MDFI | MDFIC | MDGA1 | MDGA2 | MDH1 | MDH1B | MDH2 | MDK | MDM1 | MDM2 | MDM4 | MDN1 | MDS2 | ME1 | ME2 | ME3 | MEA1 | MEAF6 | MEAF6P1 | MEAK7 | Mechanoelectrical transducer (MET) channel | Mechanosensitive Ion Channel | MECOM | MECOM-AS1 | MeCP1 histone deacetylase (HDAC) complex | MECP2 | MECR | MED1 | MED10 | MED11 | MED12 | MED12L | MED13 | MED13L | MED14 | MED14P1 | MED15 | MED15P8 | MED16 | MED17 | MED18 | MED19 | MED20 | MED21 | MED22 | MED23 | MED24 | MED25 | MED26 | MED27 | MED28 | MED29 | MED30 | MED31 | MED4 | MED4-AS1 | MED6 | MED7 | MED8 | MED9 | MEDAG | Mediator Complex | Mediator of RNA Polymerase II Transcription | MEF2A | MEF2B | MEF2C | MEF2C-AS1 | MEF2C-AS2 | MEF2D | MEFV | MEG3 | MEG8 | MEG9 | MEGF10 | MEGF11 | MEGF6 | MEGF8 | MEGF9 | MEI1