HECW2: A Potential Drug Target and Biomarker for Ubiquitin-Protein Ligase 2

Target Name: HECW2

NCBI ID: G57520

HECW2

HECW2: A Potential Drug Target and Biomarker for Ubiquitin-Protein Ligase 2

Introduction

Ubiquitin (Ub) is a protein that plays a crucial role in regulating protein-protein interactions, DNA replication, and apoptosis. Ubiquitin is also involved in the detoxification of foreign particles and damaged cells, making it an important adaptable protein that is involved in various cellular processes. The HECT, C2, and WW domain containing E3 ubiquitin protein ligase 2 (HECW2) is a protein that belongs to the E3 ubiquitin ligase family, which is responsible for the removal of Ubiquitin from target proteins. HECW2 is a 21-kDa protein that is expressed in various tissues, including liver, muscle, and heart.

HECW2 Functions

HECW2 is a key protein that is involved in the detoxification of damaged or dysfunctional proteins. It does this by recognizing and removing Ubiquitin from the target proteins. HECW2 functions as a dimeric protein that contains two distinct domains: a N-terminal HECW2-like domain and a C-terminal WW domain. The HECW2-like domain is responsible for the basic functions of the protein, including the presence of a catalytic active site and a conserved recruitment site. The C-terminal WW domain is responsible for the interaction with other proteins, including the ubiquitin-protein ligase 3 (UPL3) and the ubiquitin-protein ligase 6 (UPL6).

HECW2 as a Drug Target

HECW2 has been identified as a potential drug target due to its involvement in various cellular processes. HECW2 has been shown to play a role in the detoxification of damaged proteins, which could make it an attractive target for drugs that are aimed at repairing or regenerating damaged tissue. Additionally, HECW2 has been shown to be involved in the regulation of cellular apoptosis, which could make it an attractive target for drugs that are aimed at preventing or treating cellular apoptosis.

HECW2 as a Biomarker

HECW2 has also been shown to be involved in the regulation of protein-protein interactions, which could make it an attractive target for drugs that are aimed at modulating protein-protein interactions. Additionally, HECW2 has been shown to play a role in the detoxification of foreign particles and damaged cells, which could make it an attractive target for drugs that are aimed at removing these particles and cells from the body.

Conclusion

HECW2 is a protein that is involved in various cellular processes, including the detoxification of damaged or dysfunctional proteins, the regulation of cellular apoptosis, and the modulation of protein-protein interactions. For these reasons, HECW2 has potential as a drug target and biomarker. Further research is needed to fully understand the functions of HECW2 and its potential as a drug.

Protein Name: HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2

Functions: E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370)

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