EFCAB11: A Potential Drug Target and Biomarker for EF-Hand Domain-Containing Protein C14orf143

Target Name: EFCAB11

NCBI ID: G90141

EFCAB11

EFCAB11: A Potential Drug Target and Biomarker for EF-Hand Domain-Containing Protein C14orf143

The EF-hand domain is a unique protein structure that has been identified in a variety of organisms, including humans. It is characterized by a highly conserved amino acid sequence that is involved in the formation of ion channels and is thought to play a critical role in the function of many cellular processes. One of the most well-known proteins that contain an EF-hand domain is C14orf143, also known as EFCAB11. In this article, we will explore the potential drug target and biomarker properties of EFCAB11 and its implications for future research.

Structure and Function

The EF-hand domain is a small protein that is typically composed of 120 amino acids. It is characterized by a conserved sequence that includes a unique nucleotide repeat, known as the \"EF-loop,\" which is composed of the amino acids E, F, and C. The EF-loop is the most abundant repeat in proteins that contain an EF-hand domain and is thought to play a critical role in the formation of ion channels.

EFCAB11 is a protein that contains an EF-hand domain and is expressed in many different tissues and cells in the body. It is localized to the endoplasmic reticulum, where it is involved in the formation of vesicles and other structures that transport proteins to the cell surface. Additionally, EFCAB11 is also known to be involved in the regulation of cellular signaling pathways, including the production of reactive oxygen species (ROS) and the detoxification of xenobiotics.

Drug Target Potential

The EF-hand domain is a highly conserved structure that is found in a variety of proteins, making it an attractive target for drug development. One of the main advantages of targeting the EF-hand domain is the ability to manipulate the activity of the protein in a specific and targeted manner. This is because the EF-hand domain is involved in the formation of ion channels, which can be used to regulate the flow of nutrients, toxins, and other substances into or out of the cell.

In addition, the EF-hand domain is also involved in the regulation of cellular signaling pathways, including the production of ROS and the detoxification of xenobiotics. This makes it an attractive target for drugs that are designed to modulate these pathways. For example, studies have shown that inhibitors of the EF-hand domain have been shown to be effective in reducing the production of ROS and protecting against the detoxification of certain toxins.

Biomarker Potential

In addition to its potential as a drug target, EFCAB11 may also be a useful biomarker for certain diseases. For example, the production of ROS is often associated with the development of certain diseases, such as neurodegenerative disorders, cancer, and cardiovascular disease. Additionally, the detoxification of certain toxins, such as cadmium and arsenic, is often impaired in these diseases, which could be used as a biomarker for their diagnosis.

Conclusion

In conclusion, EFCAB11 is a protein that contains an EF-hand domain and is expressed in many different tissues and cells in the body. The EF-hand domain is thought to play a critical role in the formation of ion channels and the regulation of cellular signaling pathways. Additionally, EFCAB11 is involved in the regulation of the production of ROS and the detoxification of xenobiotics, making it an attractive target for drug development. Furthermore, the EF-hand domain is a highly conserved structure that is found in many proteins, making it a potential biomarker for certain diseases. Further research is needed to fully understand the functions of EFCAB11 and its potential as a drug target and biomarker.

Protein Name: EF-hand Calcium Binding Domain 11

The "EFCAB11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EFCAB11 comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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