EFHB: A Protein Interaction and Drug Target (G151651)

Target Name: EFHB

NCBI ID: G151651

EFHB

EFHB: A Protein Interaction and Drug Target

EFHB (EF-hand domain family member B, transcript variant 1) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is a member of the EF-hand domain family, which EFHB is a family of proteins that are characterized by the presence of a specific domain called EF-hand. EFHB is one of the four known EF-hand domain family members that have been identified in the human proteome.

The EF-hand domain is a structural protein that is characterized by the presence of a specific Rossmann-fold, which is a type of hydrogen-bonded helical structure that is thought to play a role in the protein's stability and functions. EFHB contains four known EF-hand domains, which are located at different positions on the protein sequence. The first and second EF-hand domains are located at the N-terminus of the protein, while the third and fourth domains are located at the C-terminus.

One of the unique features of EFHB is its ability to interact with other proteins. It has been shown to interact with a variety of protein, including the protein known as ALDH1L1, which is a key regulator of cell metabolism. This interaction between EFHB and ALDH1L1 has been shown to play a role in the regulation of various cellular processes, including metabolism, cell growth, and apoptosis.

Another interesting property of EFHB is its potential as a drug target. due to its unique interaction with ALDH1L1, it has been suggested as a potential target for small molecule inhibitors that could be used to treat a variety of diseases, including cancer, diabetes, and neurodegenerative diseases.

In addition to its potential as a drug target, EFHB also has important roles in several cellular processes. For example, it is involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs. It is also involved in the regulation of cell signaling, which is the process by which cells communicate with one another to control various cellular processes.

EFHB is also expressed in various tissues of the human body, including the brain, heart, and kidneys. This suggests that it may be involved in the regulation of important cellular processes that are specific to these tissues. For example, it may be involved in the regulation of neurotransmitter release from neurons, which is important for the regulation of mood, memory, and other cognitive processes.

In conclusion, EFHB is a protein that is characterized by its ability to interact with other proteins and its potential as a drug target. Its unique structure and location in various tissues make it an interesting target for small molecule inhibitors. Furthermore, its role in the Regulation of cellular processes such as cell adhesion and signaling make it important for understanding the mechanisms of various diseases.

Protein Name: EF-hand Domain Family Member B

Functions: Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (PubMed:30481768). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity)

The "EFHB Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EFHB comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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