EIF2S2: A Potential Drug Target and Biomarker (G8894)

Target Name: EIF2S2

NCBI ID: G8894

EIF2S2

EIF2S2: A Potential Drug Target and Biomarker

Eukaryotic translation initiation factor 2 (EIF2) is a protein that plays a critical role in the initiation of protein translation from mRNA to protein. EIF2 is composed of two subunits: EIF2浼? and EIF2灏?. In this article, we will focus on the EIF2灏? subunit, also known as EIF2S2, and its potential as a drug target and biomarker.

The EIF2灏? subunit is a 21-kDa protein that is expressed in various cell types, including neurons, muscle cells, and cancer cells. EIF2灏? functions as a critical regulator of protein translation, where it plays a role in the formation of the Ribosome-ribosome complex (RISC) and the transfer of amino acids to the protein chain being synthesized.

EIF2灏? has been shown to play a role in various cellular processes, including cell growth, apoptosis, and autophagy. In addition, EIF2灏? has also been linked to various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the most promising aspects of EIF2灏? is its potential as a drug target. EIF2灏? has been shown to be involved in various signaling pathways, including the PI3K/Akt signaling pathway, which is a key pathway involved in cancer progression. Additionally , EIF2灏? has also been shown to play a role in the regulation of cellular apoptosis, which is a critical mechanism that helps cells eliminate damaged or dysfunctional proteins.

In addition to its potential as a drug target, EIF2灏? has also been shown to be a potential biomarker for various diseases. For example, EIF2灏? has been shown to be downregulated in various types of cancer, including breast, ovarian, and colorectal cancer (7 ). Additionally, EIF2灏? has also been shown to be involved in the regulation of cellular aging, which is a critical factor in the development of age-related diseases.

In conclusion, EIF2S2 is a protein that has the potential to be a drug target and biomarker. Further research is needed to fully understand the role of EIF2S2 in various cellular processes and to develop effective treatments for diseases associated with its dysfunction.

Protein Name: Eukaryotic Translation Initiation Factor 2 Subunit Beta

Functions: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B

The "EIF2S2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EIF2S2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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