EFCAB8: A Potential Drug Target and Biomarker for Calcium Homeostasis

Target Name: EFCAB8

NCBI ID: G388795

EFCAB8

EFCAB8: A Potential Drug Target and Biomarker for Calcium Homeostasis

Abstract:

The EF-hand calcium-binding domain-containing protein 8 (EFCAB8) is a unique protein that plays a crucial role in maintaining calcium homeostasis. EFCAB8 is highly conserved across various species, and its function in calcium signaling is well understood. In this article , we discuss the structure and function of EFCAB8, its potential as a drug target and biomarker, and the current research on its role in calcium signaling.

Introduction:

Ca2+ is a critical signaling molecule that plays a central role in various cellular processes, including muscle contractions, nerve impulse transmission, and intracellular signaling. Ca2+ homeostasis is maintaining the optimal levels of calcium in the cells, which is essential for proper functioning of numerous cellular processes. The EF-hand calcium-binding domain-containing protein 8 (EFCAB8) is a protein that plays a crucial role in maintaining calcium homeostasis.

Structure and Function:

EFCAB8 is a 144 amino acid protein that contains a unique domain called the EF-hand calcium-binding domain. This domain is responsible for the protein's calcium-binding ability and its ability to interact with calcium ions. The EF-hand domain has been identified in various species, including humans, and its function in calcium signaling is well understood.

The EF-hand domain has three distinct regions: the N-terminal region, the central region, and the C-terminal region. The N-terminal region contains a unique aromatic residue that is involved in the protein's stability and functions as a binding site for various ligands, including calcium ions. The central region contains a parallel beta-sheet structure that is known for its stability and the presence of multiple conserved amino acids, including a calbindin-like domain. The C-terminal region contains a unique Glu- rich loop that is involved in the protein's stability and interactions with other proteins.

EFCAB8 functions as a positive regulator of calcium signaling. It has been shown to play a role in regulating the activity of various calcium channels, including the Ca2+-ATP-dependent chloride channel (Cl- channel) and the Ca2+- independent chloride channel (Ca2+ - channels). EFCAB8 has also been shown to interact with various calcium ions, including Ca2+ and Mg2+.

Drug Target and Biomarker Potential:

EFCAB8's unique domain, specifically the EF-hand calcium-binding domain, makes it an attractive drug target. Calcium ions are involved in numerous cellular processes, including muscle contractions, nerve impulse transmission, and intracellular signaling. Therefore, targeting EFCAB8 may be a promising approach to treat various diseases that are related to calcium imbalance, such as muscle weakness, myopathies, and neurodegenerative diseases.

In addition to its potential as a drug target, EFCAB8 may also be used as a biomarker for various diseases. The EF-hand domain is conserved across various species, and its function in calcium signaling is well understood. Therefore, measuring the levels of EFCAB8 in tissues or fluids may be a useful diagnostic tool for various diseases associated with calcium imbalance, such as muscle weakness, myopathies, and neurodegenerative diseases.

Current Research:

Several studies have investigated the role of EFCAB8 in calcium signaling. Several studies have shown that EFCAB8 plays a role in regulating the activity of various calcium channels, including the Ca2+-ATP-dependent chloride channel (Cl-channel) and the Ca2+- independent chloride channel (Ca2+- channels). Additionally, several studies have shown that EFCAB8 interacts with various calcium ions, including Ca2+ and Mg2+.

In addition to its role in calcium signaling, EFCAB8 has also been shown to play a role in

Protein Name: EF-hand Calcium Binding Domain 8

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•   protein structure and compound binding;
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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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