Drug Target and Biomarker: EGF (G1950)

NCBI ID: G1950

Content of Review Report on EGF Target / Biomarker

EGF

Drug Target and Biomarker: EGF

EGF binding to EGFR leads to a switch from a closed, inactive state to an open, active state.
Mutations in or near the EGF binding pocket can result in ligand-independent activation of EGFR and resistance to certain therapies.
circHBEGF can regulate the expression of EGFR and activate EGF signaling, leading to the upregulation of ECM gene expression.
EGF is involved in molecular crosstalk among signaling pathways such as hedgehog, BRAF/Ras/MAPK, Wnt, and Akt.
Anti-HER2 therapy can act through targeting EGF and its receptor, HER2, but resistance mechanisms can involve the activation of other signaling pathways.
EGF binding to EGFR triggers spatial rearrangement from monomers to dimers, higher order multimers, nanoscale clusters, clathrin-coated pits, and endosomes.
Upon EGF binding, EGFR undergoes auto-transphosphorylation and activates the Ras-MAPK pathway.
Chemical dimerizers can be used to trap EGFR dimers and study their signaling properties.

EGFR signaling in primary breast cancer is primarily associated with pro-growth and pro-survival pathways, whereas in metastatic breast cancer, STAT1 signaling is enhanced, supporting EGF-induced apoptosis.

Inhibition of the MEK/Erk signaling pathway using the drug Trametinib can bias EGFR signaling towards STAT1-mediated apoptosis.

Different levels of EGF stimulation can lead to distinct signaling pathways and outcomes. For example, EGF stimulation can lead to the upregulation of TSPAN8 expression, enhancing cell invasion and tumor metastasis.

The conformation of the JM coiled-coil region in EGFR can be influenced by the type of growth factor (EGF or TGF-alpha) bound to the extracellular domain (ECD) of the receptor.

EGF stimulation and hypoxia contribute to the transcriptional regulation of KPNA2, a gene involved in lung ADC cells. EGF upregulates KPNA2 and E2F1 expression while suppressing IRF1 expression.

These findings highlight the complex and diverse roles of EGF in different cell types and contexts, ranging from pro-growth signaling to apoptosis and transcriptional regulation.

Protein Name: Epidermal Growth Factor

Functions: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941)

The "EGF Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EGF comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets