EIF2AK3: A Potent Drug Target and Biomarker for Pyruvate Kinase-Like ER Kinase

Target Name: EIF2AK3

NCBI ID: G9451

EIF2AK3

EIF2AK3: A Potent Drug Target and Biomarker for Pyruvate Kinase-Like ER Kinase

Abstract:

EIF2AK3, also known as PKR-like ER kinase (PKRK), is a highly conserved protein that plays a critical role in the intracellular signaling pathway known as the ubiquitin-dependent pathway (PDT). EIF2AK3 is a key player in the regulation of protein stability, and its dysfunction has been implicated in various diseases, including cancer, neurodegenerative diseases, and metabolic disorders. In this article, we will discuss the EIF2AK3 protein, its functions, potential drug targets, and potential use as a biomarker.

Introduction:

The intracellular signaling pathway, also known as the ubiquitin-dependent pathway (PDT), is a complex network of genes that regulates protein stability and cell survival. The PDT is characterized by the use of the protein ubiquitin( ubiquitin) to target and modify other proteins for degradation. EIF2AK3, also known as PKRK, is a key player in this pathway and has been extensively studied for its functions in various cellular processes.

Function and Putative Functions:

EIF2AK3 is a 21-kDa protein that is highly conserved across various species, including humans. It is a non-catalytic enzyme that belongs to the family of serine/threonine protein kinases (STPKs). EIF2AK3 functions as a negative regulator of the PDT, which means that it inhibits the activity of protein kinases that are involved in the PDT.

EIF2AK3 plays a critical role in the regulation of protein stability by inhibiting the activity of the protein ubiquitin. Ubiquitin is a protein that is involved in the regulation of protein stability and is composed of a variable region and a constant region. The constant region is involved in the formation of a covalent complex with other proteins, while the variable region contains the essential catalytic and regulatory functions. EIF2AK3 functions by forming a covalent complex with the ubiquitin protein and inhibiting its activity.

The PDT is involved in various cellular processes, including cell growth, apoptosis, and metabolism. EIF2AK3 is involved in the regulation of the stability of several proteins that are involved in these processes, including the transcription factor p53, the anti-apoptotic protein Bcl- 2, and the metabolic enzyme Pyruvate Kinase (PK).

Potential Drug Targets:

EIF2AK3 is a potential drug target for various diseases, including cancer, neurodegenerative diseases, and metabolic disorders. The inhibition of EIF2AK3 function by drugs can lead to the stabilization of these proteins and potentially lead to the inhibition of their functions in disease.

EIF2AK3 has been shown to be involved in the regulation of cancer cell survival and the development of various types of cancer. EIF2AK3 has been shown to play a critical role in the regulation of cell cycle progression and the apoptosis process. It has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed.

In addition to its role in cancer, EIF2AK3 has also been implicated in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. EIF2AK3 has been shown to play a critical role in the regulation of the neurotransmitter dopamine and the protein involved in its synthesis, dopamine transporter.

In addition to its functions in cancer and neurodegenerative diseases, EIF2AK3 has also been shown to be involved in the regulation of metabolism. EIF2AK3

Protein Name: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3

Functions: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability (By similarity). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed:33384352). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity)

The "EIF2AK3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EIF2AK3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets