EIF3CL: A Protein Implicated in Translation and Cellular Processes

Target Name: EIF3CL

NCBI ID: G728689

EIF3CL

EIF3CL: A Protein Implicated in Translation and Cellular Processes

EIF3CL (Eukaryotic Translation Initiation Factor 3 Subunit 8) is a protein that plays a crucial role in the process of translation of RNA into protein in eukaryotic cells. It is a key factor in the initiation of the translation process, and its activity has been implicated in a number of cellular processes, including cell growth, apoptosis, and translation of proteins involved in disease. As a result, EIF3CL has become a focus of interest for researchers looking for new drug targets or biomarkers.

The EIF3CL protein is composed of two subunits, EIF3CL1 and EIF3CL2. EIF3CL1 is the protein that is primarily involved in the initiation of translation, while EIF3CL2 has been shown to play a role in the regulation of translation efficiency. Both subunits contain a unique domain that is specific to EIF3CL, known as the N-terminal domain. This domain is composed of a series of conserved amino acids that are involved in the formation of a protein-protein interaction network.

One of the key features of EIF3CL is its ability to interact with various cellular components, including the factors involved in translation itself. These interactions are critical for the proper functioning of the translation process, and have been implicated in a number of cellular processes. For example, studies have shown that EIF3CL can interact with the protein involved in the translation of the gene encoding the K+ channel KOXA2. This interaction is important for the proper functioning of the KOXA2 channel, which is involved in the regulation of muscle contractions and has been implicated in a number of diseases, including heart failure and hypertension.

Another study has shown that EIF3CL can interact with the protein involved in the translation of the gene encoding the protein p16INK4a. This interaction is important for the proper functioning of the p16INK4a protein, which is involved in a number of cellular processes, including cell growth and apoptosis.

In addition to its role in the initiation and regulation of translation, EIF3CL has also been shown to play a role in the regulation of cellular processes that are independent of translation. For example, studies have shown that EIF3CL can interact with the protein involved in the regulation of DNA binding, which is important for the proper functioning of a variety of cellular processes, including gene expression and DNA replication.

Given its involvement in a number of cellular processes, it is no wonder that EIF3CL has become a focus of interest for researchers looking for new drug targets or biomarkers. The ability of EIF3CL to interact with a wide range of cellular components makes it an attractive target for small molecules that can modulate its activity. Additionally, the fact that EIF3CL is involved in the regulation of translation efficiency makes it an attractive target for drugs that are designed to improve the efficiency of protein synthesis.

While the role of EIF3CL in the initiation and regulation of translation is still an area of active research, its potential as a drug target or biomarker is clear. Further studies are needed to fully understand the role of EIF3CL in cellular processes and its potential as a therapeutic agent.

Protein Name: Eukaryotic Translation Initiation Factor 3 Subunit C Like

Functions: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression

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