ATP6V1F: A Potential Drug Target and Biomarker (G9296)

Target Name: ATP6V1F

NCBI ID: G9296

ATP6V1F

ATP6V1F: A Potential Drug Target and Biomarker

Introduction

ATP (adenosine triphosphate) is a crucial molecule in various cellular processes, including muscle muscle, nerve transmission, and brain function. ATP is synthesized fromADP (nucleotide diphosphate) and a phosphate molecule, where the phosphate molecule is composed of a nucleotide molecule and Composed of three phosphate groups. ATP is highly specific within cells and is the main energy supplier within cells. However, abnormal levels in some diseases also contribute to the development of tumors. Therefore, studying the role and regulatory mechanism of ATP in diseases has important clinical significance.

ATP6V1F: a molecule of interest for a long time

Recently, researchers discovered a molecule called ATP6V1F, which is expressed in a variety of cancers. ATP6V1F is a 65kDa protein and a member of the ATPase family. This family includes many important enzymes, such as ATP6V0, ATP6V2, ATP6V3 and ATP6V4, etc., which play a key role in regulating intracellular ATP levels. The discovery of ATP6V1F has attracted widespread attention from biologists because its role in tumor development and progression is still not fully understood.

Mechanism of action of ATP6V1F

The mechanism by which ATP6V1F functions within cells is not fully understood. However, studies have shown that this molecule is abnormally expressed in a variety of cancers and is closely related to tumor occurrence and development. ATP6V1F can affect ATP levels in a variety of ways, including:

1. Regulate ATPase activity

ATP6V1F is an ATPase that catalyzes the hydrolysis of ATP molecules into ADP and phosphate molecules. Studies have found that the activity of ATP6V1F is affected by multiple factors, including substrate concentration, inhibitors and regulators. These factors can affect the conformation of ATP6V1F, thereby affecting the catalytic efficiency of ATP.

1. Participate in ATP signaling

ATP, as the direct energy molecule in cells, plays an important role in the signal transduction process. ATP6V1F is abnormally expressed in a variety of cancers and may be related to signaling pathways in tumorigenesis and development. Studies have found that ATP6V1F can participate in the ATP-dependent kinase (APK) signaling pathway. This pathway plays an important role in tumor growth and progression. Therefore, studying the role of ATP6V1F in this pathway has important clinical significance.

1. Participate in cell cycle regulation

ATP plays a key role in cell cycle regulation. ATP6V1F is abnormally expressed in a variety of cancers and may be related to the cycle regulation of tumor cells. Studies have found that ATP6V1F can participate in the S phase of the cell cycle. At this stage, ATP6V1F may contribute to DNA replication and chromosome structural stability. In addition, ATP6V1F can also participate in the regulation of G1 and G2 phases, thereby affecting the progression of the cell cycle.

1. Participate in the invasion and metastasis of tumor cells

ATP plays an important role in the invasion and metastasis of tumor cells. ATP6V1F is abnormally expressed in a variety of cancers and may be related to the invasion and metastasis of tumor cells. Studies have found that ATP6V1F can participate in the invasion and metastasis process of tumor cells, including cell adhesion, cell migration and tumor cell metastasis.

Clinical significance of ATP6V1F

ATP6V1F is abnormally expressed in a variety of cancers, and its mechanism of action is still not fully understood. However, the discovery of ATP6V1F attracted widespread attention from biologists. Because its role in tumor occurrence and development is still not fully understood, studying the biological functions of ATP6V1F has important clinical significance.

First, studying ATP6V1F can provide new therapeutic targets for tumor patients. By inhibiting the activity of ATP6V1F, the growth and spread of tumor cells can be slowed down, thereby bringing better therapeutic effects to patients.

Secondly, studying ATP6V1F can be a tumor molecule

Protein Name: ATPase H+ Transporting V1 Subunit F

Functions: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)

The "ATP6V1F Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ATP6V1F comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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