RNF144A: A Potential Drug Target and Biomarker (G9781)
RNF144A: A Potential Drug Target and Biomarker
The RNA-protein complex, composed of RNA and protein entities, plays a crucial role in various cellular processes. One of the key components of this complex is the RNA non-coding protein known as RNF144A. RNF144A is a 21-kDa protein that is expressed in various tissues and cells, including the brain, heart, liver, and pancreas. Its function in these cells is not well understood, but research has shown that it is involved in various cellular processes, including cell survival, metabolism, and inflammation. As a result, RNF144A has been identified as a potential drug target and biomarker.
The discovery and characterization of RNF144A
RNF144A was first identified as a protein that was expressed in the brain and was shown to localize to the endoplasmic reticulum (ER) and to be involved in the export of proteins from the ER to the cytoplasm. Subsequently, studies have shown that RNF144A is involved in various cellular processes, including the regulation of cell survival, metabolism, and inflammation.
One of the most significant findings related to RNF144A is its role in cell survival. Studies have shown that RNF144A is involved in the regulation of cell survival by preventing the apoptosis of neurons. This is done by interacting with several transcription factors, including p53, and by modulating the levels of cellular stress proteins, such as activator-induced cytidine deaminase (AID). These findings imply that RNF144A may be a potential drug target for neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Another function of RNF144A is its role in metabolism. Studies have shown that RNF144A is involved in the regulation of protein synthesis and metabolism by interacting with the protein ubiquitin. This interaction allows RNF144A to modulate the levels of ubiquitin on target proteins, which can influence protein stability and localization. These findings imply that RNF144A may be a potential drug target for diseases characterized by the accumulation of misfolded proteins, such as cancer.
In addition to its role in cell survival and metabolism, RNF144A is also involved in the regulation of inflammation. Studies have shown that RNF144A is involved in the regulation of inflammation by interacting with the transcription factor NF-kappa-B. This interaction allows RNF144A to modulate the levels of NF-kappa-B activity and the production of pro-inflammatory cytokines. These findings imply that RNF144A may be a potential drug target for diseases characterized by inflammation, such as rheumatoid arthritis, inflammatory bowel disease, and chronic obstructive pulmonary disease (COPD).
Potential drug targeting strategies
The potential drug targeting strategies for RNF144A are vast and include the inhibition of its activity, the modulation of its expression, and the use of small molecules and antibodies to interact with its activity.
One of the most promising strategies for targeting RNF144A is the inhibition of its activity by small molecules. Many small molecules have been shown to interact with RNF144A and to modulate its activity. For example, studies have shown that the small molecule drug and technology, called 纬-secretase inhibitors, can inhibit the activity of RNF144A and protect against neurodegenerative diseases.
Another promising strategy for targeting RNF144A is the modulation of its expression by small molecules. Many small molecules have been shown to interact with RNF144A and to modulate its expression levels. For example, studies have shown that the small molecule drug and technology, called RNA- protein interactions modulators, can
Protein Name: Ring Finger Protein 144A
Functions: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC
The "RNF144A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF144A comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
RNF144B | RNF145 | RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38 | RNF39 | RNF4 | RNF40 | RNF41 | RNF43 | RNF44 | RNF5 | RNF5P1 | RNF6 | RNF7 | RNF7P1 | RNF8 | RNFT1 | RNFT2 | RNGTT | RNH1 | RNLS | RNMT | RNPC3 | RNPC3-DT | RNPEP | RNPEPL1 | RNPS1 | RNPS1P1 | RNR1 | RNR2 | RNU1-1 | RNU1-100P | RNU1-108P | RNU1-11P | RNU1-134P | RNU1-18P | RNU1-3 | RNU1-31P | RNU1-32P | RNU1-36P | RNU1-38P | RNU1-4 | RNU1-42P | RNU1-55P | RNU1-61P | RNU1-63P | RNU1-72P | RNU1-73P | RNU1-78P
